477-52-1Relevant academic research and scientific papers
NOVEL DERIVATIVE OF BETA-APOPICROPODOPHYLLIN AND METHOD OF PREPARING THEREOF
-
Paragraph 0031-0033, (2021/11/13)
Provided are a novel derivative of β-apopicropodophyllin and a method of preparing the same, and more particularly, a compound represented by Formula 1 below, which is a novel derivative of β-apopicropodophyllin derived from podophyllotoxin, which is an anticancer agent, a method of preparing the same, and a composition for treating cancer, which includes the compound. In Formula 1, R is a C2 to C10 alkyl group, a C2 to C10 alkyl group containing an allyl- or alkyne, a —[CH2]n—C3 to C8 cycloalkyl group, a substituted or unsubstituted —[CH2]n-phenyl group, a substituted or unsubstituted —[CH2]n—C5 to C6 heteroaromatic group, a —C(═O)—C1 to C8 alkyl group, a substituted or unsubstituted —C(═O)—[CH2]n-phenyl group, or a substituted or unsubstituted —C(═O)—[CH2]n—C5 to C6 heteroaromatic group, wherein n is an integer of 0 to 6.
Concise synthesis of (+)-β- and γ-apopicropodophyllins, and dehydrodesoxypodophyllotoxin
Xiao, Jian,Nan, Guangming,Wang, Ya-Wen,Peng, Yu
, (2018/11/30)
Herein, we present an expeditous synthesis of bioactive aryldihydronaphthalene lignans (+)-β- and γ-apopicropodophyllins, and arylnaphthalene lignan dehydrodesoxypodophyllotoxin. The key reaction is regiocontrolled oxidations of stereodivergent aryltetralin lactones, which were easily accessed from a nickel-catalyzed reductive cascade approach developed in our group.
Total Synthesis of the Claimed Structure of (±)-Hyptinin and Structural Revision of Natural Hyptinin
Maeda, Kazuto,Hamada, Toshiyuki,Onitsuka, Satoaki,Okamura, Hiroaki
, p. 1446 - 1449 (2017/05/31)
A total synthesis of (±)-hyptinin was achieved via a convergent route using the key phosphonate, cyclic ketone, and aryl Grignard components. The 1H and 13C NMR spectra of natural hyptinin did not agree with those of the synthesized
Complete assignments of 1H and 13C NMR spectral data for 7, 7'-dihydroarylnaphthalene lignan lactones
Da Silva, Rosangela,Batista, Joao Henrique Carvalho,Da Silva Maringolo, Carine,Donate, Paulo Marcos
experimental part, p. 523 - 526 (2010/04/30)
In this article we present a complete H and C NMR spectral analysis of three 7, 7'-dihydroarylnaphthalene lignan lactones using modern NMR techniques such as COSY, HSQC, HMBC and NOE experiments. Complete assignment and homonuclear hydrogen coupling const
Asymmetric Total Synthesis of (-)-Podophyllotoxin
Andrews, Robert C.,Teague, Simon J.,Meyers, A. I.
, p. 7854 - 7858 (2007/10/02)
Using a diastereoselective addition of the appropriate aryllithium to a naphtalene-containing chiral oxazoline leads to advanced intermadiate 11 in the podophyllotoxin series.The latter is obtained in a 92:8 de.Transformation of the oxazoline moiety to the requisite lactone 18 followed by invoking the Kende route to the target gave natural (-)-podophyllotoxin in 94 percent ee.The overall yield of the sequence, accomplished in 24 steps, was 5 percent.
