4770-26-7

Usage

Structure

Cyclic imide derivative with a substituted ethyl group and a hydroxy and phenyl group attached to the carbon atoms

Pharmaceutical applications

Potential central nervous system stimulant, potential treatment for attention deficit hyperactivity disorder (ADHD)

Other potential activities

Antihypertensive, vasodilator, and anti-inflammatory agent

Additional research needed

Further studies required to fully understand the potential uses and effects of this chemical compound.

Upstream product

• 63620-04-2 2-propyl-benzoyl chloride 
• 2438-03-1 2-(n-Propyl)-benzoesaeure 
• 520-03-6 N-phenylphthalimide 
• 557-20-0 diethylzinc 
• 327-62-8 potassium propionate 

Downstream Products

• 1532556-75-4 3-ethyl-2-phenylisoindolin-1-one 
• 4770-27-8 3-ethylidene-2-phenylisoindolin-1-one 
• 1532556-76-5 3-ethyl-3-methoxy-2-phenylisoindolin-1-one 
• 32346-23-9 (Z)-3-ethylidene-2-phenylisoindolin-1-one 
• 32346-24-0 (E)-3-ethylidene-2-phenylisoindolin-1-one 

Relevant academic research and scientific papers

Copper-catalyzed aerobic double functionalization of benzylic C(sp3)-H bonds for the synthesis of 3-hydroxyisoindolinones

A copper-catalyzed aerobic 3-hydroxyisoindolinone synthesis was developed via the benzylic double C(sp3)-H functionalization of 2-alkylbenzamides. In this reaction, molecular oxygen was used as both an oxidant for C(sp3)-H functionalization and an oxygen source. Our method can be extended to diverse benzylic C(sp3)-H bonds and shows excellent functional group tolerance. This journal is

Decarbonylative cross coupling of phthalimides with diorganozinc reagents - Efforts toward catalysis

The decarbonylative coupling of phthalimides with diorganozinc reagents to form o-substituted benzamides has been previously demonstrated as a viable process, but only with stoichiometric nickel(0). Investigations into a number of reaction variables, incl

Nickel-catalyzed direct addition of diorganozinc reagents to phthalimides: Selective formation of gamma-hydroxylactams

The nickel-catalyzed addition of diorganozinc reagents to phthalimides proceeds with excellent selectivity to provide 3-substituted-3- hydroxyisoindolin-1-one products. These 3-hydroxy-γ-lactams are produced cleanly in high yield with numerous examples of imide substitution and a broad range of diorganozinc reagents that are prepared and utilized without purification. Georg Thieme Verlag Stuttgart · New York.

The photodecarboxylative addition of carboxylates to phthalimides: Scope and limitations

Intermolecular photoinduced decarboxylative additions of a series of alkylcarboxylates to N-substituted phthalimides gave the corresponding hydroxyphthalimidines in moderate to high yields of 39-89%. The potassium salt of 1-adamantanecarboxylic acid predominately underwent simple decarboxylation when irradiated in the presence of N-methylphthalimide. In case of phthalimides carrying suitable leaving groups within the N-side chain, decarboxylation, retro-Aldol cleavage or decarbonylation preceded the intermolecular addition step.

Photodecarboxylative addition of carboxylates and ct-keto carboxylates to phthalimides

Intermolecular photoinduced decarboxylative additions of formate and a series of alkyl carboxylates as well as a-keto carboxylates to N-substituted phthalimides la-c and N-phthaloyl amino acid esters 3a-i gave hydroxy phthalimidines 2a-2j, 6a, b, 9 and hydroxy phthalimidine methyl esters 4a-4i in moderate to high yields. Only in one case (adamantane derivative 10) imide-catalyzed decarboxylation to give the corresponding hydrocarbon was observed. Thieme Stuttgart-.