32346-23-9

Upstream product

• 520-03-6 N-phenylphthalimide 
• 925-90-6 ethylmagnesium bromide 
• 16859-59-9 3-hydroxy-1(3H)-isobenzofuranone 
• 1351765-45-1 (E)-N-phenyl-2-(prop-1-enyl)benzamide 
• 68692-74-0 (E)-2-(prop-1-en-1-yl)benzoic acid 
• 70913-21-2 (E)-1-bromo-2-(2-methylethenyl)benzene 
• 62-53-3 aniline 
• 201230-82-2 carbon monoxide 
• 14752-72-8 1,N-Diphenylpropanimine 
• 4770-26-7 3-ethyl-3-hydroxy-2-phenyl-2,3-dihydroisoindol-1-one 

Relevant academic research and scientific papers

Influence of N-Substitution in 3-Alkyl-3-hydroxyisoindolin-1-ones on the Stereoselectivity of Br?nsted Acid-Catalyzed Synthesis of 3-Methyleneisoindolin-1-ones

A comprehensive study on the influence of N-substitution on the stereoselective outcome of the synthesis of 3-methyleneisoindolin-1-ones from 3-alkyl-3-hydroxyisoindolin-1-ones is reported. The study was performed on an array of structurally diverse 3-alkyl-3-hydroxyisoindolin-1-ones with tunable sizes of N-substituents. In a methanesulfonic acid-catalyzed reaction, substrates without N-substituent (N?H) afforded exclusively the Z-isomer, while an increase in their size was followed by the formation of a stereoisomeric mixture with the E-isomer as the major component.

Rhodium-Catalyzed Cyclocarbonylation of Ketimines via C-H Bond Activation

A novel rhodium-catalyzed oxidative cyclocarbonylation of ketimines via cleavage of two C-H bonds was established, which provided a direct and reliable method for the synthesis of a wide range of 3-methyleneisoindolin-1-ones with mostly moderate yields. P

Regioselective Pd-catalyzed aerobic aza-Wacker cyclization for preparation of isoindolinones and isoquinolin-1(2 H)-ones

A switchable regioselective intramolecular aerobic aza-Wacker cyclization catalyzed by palladium is presented. Isoindolinones or isoquinolin-1(2H)-ones could be prepared selectively from the same substrates using different catalysts. The type and steric hindrance of the ligands may be the variables most significant for regiocontrol.