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1-(5-Hydroxyindolin-1-yl)ethanone, also known as 5-hydroxyindole-2-carboxaldehyde, is a chemical compound characterized by a benzene ring fused to a five-membered ring with an attached ketone group. It serves as a key intermediate in the biosynthesis of the neurotransmitter serotonin, playing a crucial role in the modulation of mood, appetite, and sleep.
Used in Pharmaceutical Industry:
1-(5-Hydroxyindolin-1-yl)ethanone is used as a key intermediate for the production of pharmaceuticals, particularly in the synthesis of serotonin-targeting drugs, due to its unique chemical structure and properties.
Used in Neurological Disorder Treatment:
1-(5-Hydroxyindolin-1-yl)ethanone is used as a potential therapeutic agent for the treatment of neurological disorders, such as depression, anxiety, and sleep disorders, for its ability to modulate serotonin levels in the brain.
Used in Research and Development:
1-(5-Hydroxyindolin-1-yl)ethanone is used as a research compound in preclinical studies to explore its potential applications in modulating serotonin levels and its effects on various neurological conditions, contributing to the advancement of our understanding of serotonin-related disorders and the development of novel therapeutic strategies.

4770-32-5

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4770-32-5 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 4770-32-5 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,7,7 and 0 respectively; the second part has 2 digits, 3 and 2 respectively.
Calculate Digit Verification of CAS Registry Number 4770-32:
(6*4)+(5*7)+(4*7)+(3*0)+(2*3)+(1*2)=95
95 % 10 = 5
So 4770-32-5 is a valid CAS Registry Number.

4770-32-5SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 1-(5-hydroxy-2,3-dihydroindol-1-yl)ethanone

1.2 Other means of identification

Product number -
Other names 1-Acetyl-5-indolinol

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4770-32-5 SDS

4770-32-5Downstream Products

4770-32-5Relevant academic research and scientific papers

BROMODOMAIN INHIBITOR

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Paragraph 0246, (2016/10/31)

The present invention relates to substituted heterocyclic derivative compounds, compositions comprising said compounds, and the use of said compounds and compositions for epigenetic regulation by inhibition of bromodomain-mediated recognition of acetyl lysine regions of proteins, such as histones. Said compositions and methods are useful for the treatment of cancer and neoplastic disease.

Identification of a potent and selective 5-HT1B receptor antagonist

Wyman, Paul A.,Marshall, Howard R.,Flynn, Sean T.,King, Ron J.,Thompson, Mervyn,Smith, Paul W.,Hadley, Michael S.,Price, Gary W.,Scott, Claire M.,Dawson, Lee A.

, p. 4708 - 4712 (2007/10/03)

An SAR study around the mixed 5-HT1ABD receptor antagonist SB-272183 found that introduction of cis-2,6-dimethyl substitution onto the piperazine ring was a key structural change, which imparted a combination of both excellent selectivity over

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