16078-35-6

Basic information

• Product Name: 1 5-DIACETYLINDOLINE 97
• Synonyms: 1 5-DIACETYLINDOLINE 97;1,1'-(Indoline-1,5-diyl)diethanone;1-(1-acetyl-2,3-dihydroindol-5-yl)ethanone
• CAS NO: 16078-35-6
• Molecular Formula: C₁₂H₁₃NO₂
• Molecular Weight: 203.24
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Indoles
• Mol File: 16078-35-6.mol
• Article Data: 6

Chemical Properties

• Melting Point: 137-141 °C(lit.)
• Boiling Point: 471.6°C at 760 mmHg
• Flash Point: 240.8°C
• Appearance: /
• Density: 1.179g/cm³
• Vapor Pressure: 4.58E-09mmHg at 25°C
• Refractive Index: 1.57
• CAS DataBase Reference: 1 5-DIACETYLINDOLINE 97(CAS DataBase Reference)
• NIST Chemistry Reference: 1 5-DIACETYLINDOLINE 97(16078-35-6)
• EPA Substance Registry System: 1 5-DIACETYLINDOLINE 97(16078-35-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• WGK Germany: 3
• Hazardous Substances Data: 16078-35-6(Hazardous Substances Data)

Usage

Uses

Reactant for α-arylation reactionsReactant for preparation of 5-HT1B receptor antagonistsReactant for synthesis of N-(1-benzo[1,3]dioxol-5-yl)ethyl-, N-[1-(2,3-dihydro-benzofuran-5-yl)ethyl-, and N-[1-(2,3-dihydro-1H-indol-5-yl)ethylacrylamides as KCNQ2 opener agentsReactant for preparation of 1-acyl-7-nitroindolines as L-glutamate photoreleasing agents in cerebellar granule neurons

InChI:InChI=1/C12H13NO2/c1-8(14)10-3-4-12-11(7-10)5-6-13(12)9(2)15/h3-4,7H,5-6H2,1-2H3

Upstream product

• 16078-30-1 1-Acetyl-2,3-dihydro-1H-indole 
• 75-36-5 acetyl chloride 
• 496-15-1 1-indoline 
• 67-64-1 acetone 

Downstream Products

• 1337532-08-7 5-{1-[(2,5-difluorophenyl)acetyl]-2,3-dihydro-1H-indol-5-yl}furo[2,3-d]pyrimidin-4-amine 
• 1213251-54-7 C₁₈H₁₆FNO₂ 
• 53330-94-2 1-(1H-indol-5-yl)ethanone 
• 239135-34-3 methyl 1-[S-(4-amino-4-carboxybutanoyl)]-7-nitroindoline-5-acetate 
• 765945-13-9 N-[1-(2,3-dihydro-1H-indol-5-yl)-ethyl]-3-(2-fluoro-phenyl)-acrylamide 
• 4770-32-5 1-(5-hydroxy-2,3-dihydroindol-1-yl)ethanone 
• 16078-34-5 5-Acetyl-2,3-dihydro-1H-indole 
• 67932-65-4 5-ethyl-2,3-dihydro-1H-indole 

Relevant articles and documents

Indoleline compounds and derivatives thereof, preparation methods, pharmaceutical compositions and applications

The present invention discloses a class of indoleline compounds and derivatives thereof, preparation methods, pharmaceutical compositions and applications. The structure of such indoleline compounds is as follows formula (I), the derivatives thereof relate to stereoisomers of the indole compound, tautomers, metabolites, metabolic precursors, prodrugs, solvates, salts of solvates, crystals, pharmaceutically acceptable salts or mixtures thereof. This class of indoleline compounds and their derivatives has a significant inhibitory effect on the activity of indoleamine 2,3-bioxygenase 1, can be used to prepare drugs for the treatment of indoleamine 2,3-bioxygenase-mediated immunosuppression-related diseases, by activating the host immune response to exert antitumor activity.

Identification of a potent and selective 5-HT1B receptor antagonist

An SAR study around the mixed 5-HT1ABD receptor antagonist SB-272183 found that introduction of cis-2,6-dimethyl substitution onto the piperazine ring was a key structural change, which imparted a combination of both excellent selectivity over

THE SYNTHESIS OF 5- and 7-ACETYLINDOLE DERIVATIVES. I. THE PHOTOCHEMICAL REARRANGEMENT OF 1-ACETYLINDOLINE

5- and 7-Acetyl substituted indole derivatives have been prepared via intramolecular photo rearrangement of acyl radical and intramolecular electrophilic acylation of 1-acetylindoline.