4770-37-0

Basic information

• Product Name: indolin-6-ol
• Synonyms: indolin-6-ol;1h-indol-6-ol,2,3-dihydro-;6-Hydroxyindoline
• CAS NO: 4770-37-0
• Molecular Formula: C₈H₉NO
• Molecular Weight: 135.1632
• Mol File: 4770-37-0.mol
• Article Data: 10

Chemical Properties

• Boiling Point: 302.4 °C at 760 mmHg
• Flash Point: 178.3 °C
• Appearance: /
• Density: 1.196 g/cm³
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 10.44±0.20(Predicted)
• CAS DataBase Reference: indolin-6-ol(CAS DataBase Reference)
• NIST Chemistry Reference: indolin-6-ol(4770-37-0)
• EPA Substance Registry System: indolin-6-ol(4770-37-0)

Safety Data

• Hazardous Substances Data: 4770-37-0(Hazardous Substances Data)

Usage

General Description

Indolin-6-ol, also known as 1H-indole-6-ol, is a chemical compound with the molecular formula C8H7NO. It is a derivative of indole, a heterocyclic organic compound. Indolin-6-ol is commonly used in the synthesis of various organic compounds and pharmaceuticals due to its versatile reactivity and functional groups. It has been found to exhibit antioxidant, antibacterial, and cytotoxic properties, making it a potential candidate for drug development. Additionally, indolin-6-ol has been investigated for its potential use in the treatment of cancer and neurodegenerative diseases. Overall, indolin-6-ol plays a crucial role in organic synthesis and pharmaceutical research due to its diverse range of chemical properties and potential therapeutic applications.

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Relevant articles and documents

Pd/C-Catalyzed transfer hydrogenation ofN-H indoles with trifluoroethanol and tetrahydroxydiboron as the hydrogen source

Under the guidance of the known mechanism of the hydrogenation of indoles and transfer hydrogenation with tetrahydroxydiboron (B2(OH)4), Pd/C catalyzed transfer hydrogenation ofN-H indoles with trifluoroethanol and tetrahydroxydiborane as the hydrogen source has been developed. This provides an efficient strategy and catalytic system for the reduction of un-activatedN-H indoles, andN-H indolines are obtained with good to excellent yields. In addition, a series of the isotopic labelling experiments were carried out to probe the mechanism.

NERVE-SPECIFIC FLUOROPHORE FORMULATIONS FOR DIRECT AND SYSTEMIC ADMINISTRATION

Nerve-specific fluorophore formulations for direct or systemic administration are described. The formulations can be used in fluorescence-guided surgery (FGS) to aid in nerve preservation during surgical interventions.

RORγ MODULATORS

The invention provides an RORγ receptor agonist comprising a compound of formula (I), wherein the variables are as defined herein. These compounds are analogous to known RORγ receptor antagonists. The invention further provides a method of activating -the nuclear receptor RORγ, comprising -contacting the RORγ with an effective amount or concentration of a compound of the invention; and a method of treating cancer in a patient, comprising administering to the patient an effective dose of a compound of the invention.