15918-79-3

Basic information

• Product Name: Indolin-6-amine
• Synonyms: 2,3-Dihydro-1H-indol-6-amine 2HCl
• CAS NO: 15918-79-3
• Molecular Formula: C₈H₁₀N₂
• Molecular Weight: 134.1784
• Mol File: 15918-79-3.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 304.1±31.0 °C(Predicted)
• Appearance: /
• Density: 1.148±0.06 g/cm3(Predicted)
• PKA: 5.71±0.20(Predicted)
• CAS DataBase Reference: Indolin-6-amine(CAS DataBase Reference)
• NIST Chemistry Reference: Indolin-6-amine(15918-79-3)
• EPA Substance Registry System: Indolin-6-amine(15918-79-3)

Safety Data

• Hazardous Substances Data: 15918-79-3(Hazardous Substances Data)

Upstream product

• 5318-27-4 6-amino-1H-indole 
• 129488-00-2 6-amino-2,3-dihydroindole-1-carboxylic acid tert-butyl ester 
• 496-15-1 1-indoline 
• 19727-83-4 6-nitroindoline 

Downstream Products

• 1333239-03-4 C₂₉H₃₃N₃O₃ 
• 7556-21-0 1-methyl-2,3-dihydro-indol-6-ol 
• 4770-37-0 6-hydroxy-indoline 
• 683746-20-5 trans-N-(1-Benzyl-piperidin-4-yl)-N-(2,3-dihydro-1H-indol-6-yl)-3-phenyl-acrylamide 

Relevant articles and documents

Indoline Catalyzed Acylhydrazone/Oxime Condensation under Neutral Aqueous Conditions

Acylhydrazones formation has been widely applied in materials science and biolabeling. However, their sluggish condensation rate under neutral conditions limits its application. Herein, indolines with electron-donating groups are reported as a new catalyst scaffold, which can catalyze acylhydrazone, hydrazone, and oxime formation via an iminium ion intermediate. This new type of catalyst showed up to 15-fold rate enhancement over the traditional anilinecatalyzed reaction at neutral conditions. The identified indoline catalyst was successfully applied in hydrogel formation.

High-Temperature Boc Deprotection in Flow and Its Application in Multistep Reaction Sequences

A simplified Boc deprotection using a high-temperature flow reactor is described. The system afforded the qualitative yield of a wide variety of deprotected substrates within minutes using acetonitrile as the solvent and without the use of acidic conditions or additional workups. Highly efficient, multistep reaction sequences in flow are also demonstrated wherein no extraction or isolation was required between steps.

STEROID RECEPTOR MODULATOR COMPOUNDS AND METHODS

Non-steroidal compounds which are high affinity, high selectivity modulators for steroid receptors are disclosed. Also disclosed are pharmaceutical compositions incorporating such compounds, methods for employing the disclosed compounds and compositions for treating patients requiring steroid receptor agonist or antagonist therapy, intermediates useful in the preparation of the compounds and processes for the preparation of the steroid receptor modulator compounds.