4770-68-7Relevant articles and documents
Hantzsch ester triggered metal-free cascade approach to isoindolinones
Tian, Youping,Wei, Junmei,Wang, Meng,Li, Gaoqiang,Xu, Feng
supporting information, p. 1866 - 1870 (2018/04/14)
Disclosed herein is an expedient synthesis of biologically important isoindolinone derivatives from reactions of 2-formylbenzoic acids with various amines. This method operates via a deliberately designed catalyst-free tandem reductive amination/cyclization cascade event triggered by a transfer hydrogenation process with easily available Hantzsch ester as the organic hydride source. The ease of operation, mild reaction conditions, facile accessibility of the starting materials, and easy scalability of the current method distinguish it from the other precedent protocols, thus enable it a practical approach to the syntheses of valuable isoindolinone-incorporated drugs.
Copper-Catalyzed sp3 C-H Aminative Cyclization of 2-Alkyl-N-arylbenzamides: An Approach for the Synthesis of N-Aryl-isoindolinones
Nozawa-Kumada, Kanako,Kadokawa, Jun,Kameyama, Takehiro,Kondo, Yoshinori
, p. 4479 - 4481 (2015/09/28)
The synthesis of isoindolinones via copper-catalyzed sp3 C-H functionalization of 2-alkyl-N-substituted benzamides is described. This process does not require the preparation of halogenated substitutes, expensive transition metals, or toxic Sn or CO gas. This method provides an efficient approach to generate various functionalized isoindolinones.
Direct one-pot cobalt(II) phthalocyanine catalyzed synthesis of N-substituted isoindolinones
Kumar, Vishal,Sharma, Upendra,Singh, Bikram,Kumar, Neeraj
, p. 1594 - 1598 (2013/02/25)
A direct one-pot synthetic approach is described wherein cobalt(II) phthalocyanine (CoPc) catalyzed reductive amination of 2-carboxybenzaldehyde, followed by intramolecular amidation afforded N-substituted isoindolinones. The method used diphenylsilane as reducing agent in ethanol. High chemoselectivity with excellent yield was obtained in most of the studied substrates.
