4771-92-0

Upstream product

• 23451-96-9 2-amino-5-methylthiophenol 
• 6281-61-4 1-benzoyl-3-(4-methylphenyl)thiourea 
• 98-88-4 benzoyl chloride 
• 532-55-8 Benzoyl isothiocyanate 
• 29289-13-2 2-iodo-4-methylaniline 
• 2536-91-6 6-methylbenzothiazol-2-ylamine 

Downstream Products

• 91506-77-3 6-Methyl-2-(5-phenyl-tetrazol-1-yl)-benzothiazole 

Relevant academic research and scientific papers

N-Iodosuccinimide mediated intramolecular oxidative C(sp 2)-S bond formation for the synthesis of 2-aminobenzothiazole derivatives

An extremely efficient synthetic method for the preparation of 2-aminobenzothiazole derivatives starting from arylthioureas by using N-iodosuccinimide has been reported. This protocol features a mild reaction conditions, a short reaction time, and metal-free oxidative conditions for C (sp 2)-S bond construction.

Copper promoted C-S and C-N cross-coupling Reactions:The synthesis of 2-(N-Aryolamino)benzothiazoles and 2-(N-Aryolamino)benzimidazoles

The synthesis of 2-(N-aryolamino)benzothiazoles and 2-(N-aryolamino)benzimidazoles has been accomplished in the presence of copper catalyst. These reactions involve C-S and C-N cross-coupling reaction. All electron donating and withdrawing substituent's readily underwent the reaction to give target products in good to excellent yield. In addition, the reaction also gave target product in high yield with bulk scale.

PTSA catalyzed straightforward protocol for the synthesis of 2-(N-acyl)aminobenzimidazoles and 2-(N-acyl)aminobenzothiazoles in PEG

An efficient PTSA catalyzed synthesis of 2-(N-acyl)aminobenzimidazoles and 2-(N-acyl)aminobenzothiazoles has been described using S-ethylated-N- acylthioureas as substrates and polyethylene glycol as solvent.

Synthesis of N-substituted-2-Aminobenzothiazoles by ligand-Free copper(I)-Catalyzed cross-Coupling reaction of 2-haloanilines with isothiocyanates www.eurjoc.org

A novel and efficient formation of N-substituted-2-aminobenzothiazoles by a ligand-free copper(I)-catalyzed one-pot cascade process was developed. A variety of isothiocyanates coupled with 2-iodoanilines to give N-substituted-2-amino-benzothiazoles in mod

Cyclization process for substituted benzothiazole derivatives

The present invention relates to a process for preparation of amino substituted benzothiazole derivatives of formula I wherein R1, R2 and R3 are independently from each other hydrogen, lower alkyl, lower alkoxy or halogen; R4 is hydrogen, lower alkyl, lower alkyloxy, halogen, or is a five or six membered non aromatic heterocyclyl group, unsubstituted or substituted by lower alkyl or an oxo-group, or is —NR5R6, wherein R5 and R5 are independently from each other hydrogen, lower alkyl, —C(O)-lower alkyl, —(CH2)nO-lower alkyl or benzyl, opionally substituted by lower alkyl, or is an five or six membered heteroaryl group; R1 and R2 or R2 and R3 may form together with the corresponding carbon atoms a ring containing —O—CH2—O— or —CH═CH—CH═CH—; R is hydrogen or —C(O)R′; R′ is a five or six membered non aromatic heterocyclyl group, five or six membered heteroaryl group or is aryl, which rings may be substituted by the groups, selected from lower alkyl, halogen-lower alkyl, lower alkoxy, cyano, nitro, —C(O)H, —C(O)OH or by pyrrolidin-1-yl-methyl; n is 1 to 4; or a pharmaceutically acceptable salt thereof, wherein the cyclization is carried out by the treatment of a compound of formula with sulphoxide/HBr/solvent to give the desired products of formula I for R is hydrogen (formula IA) or for R is —C(O)R′ (formula IB)

Synthesis, Photolysis and Pyrolysis of 1-(2'-Benzothiazolyl)-5-aryltetrazoles

Aroylaminobenzothiazoles (II), have been converted into 1-(2'-benzothiazolyl)-5-aryltetrazoles (IV) by treatment with PCl5 followed by azidolysis with sodium azide in aequeous acetone solution.Pyrolysis of IV in tetralin affords exclusively 2-aryl-s-triaz