4773-33-5

Basic information

• Product Name: ETHYL ALPHA-CHLOROPHENYLACETATE
• Synonyms: ETHYL ALPHA-CHLOROPHENYLACETATE;ETHYL A-CHLOROPHENYLACETATE;1-CHLORO-1-PHENYLACETIC ACID ETHYL ESTER;ethyl-1-chlorophenylacetate;Ethyl-chlorophenylacetate;-Chlorophenylacetic acid ethyl ester;2-Chloro-2-phenylacetic acid ethyl ester;Phenylchloroacetic acid ethyl ester
• CAS NO: 4773-33-5
• Molecular Formula: C₁₀H₁₁ClO₂
• Molecular Weight: 198.65
• EINECS: 225-315-2
• Product Categories: Pharmaceutical Intermediates;API Intermediate
• Mol File: 4773-33-5.mol
• Article Data: 7

Chemical Properties

• Boiling Point: 68-72 °C0.3 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.157 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.0141mmHg at 25°C
• Refractive Index: n20/D 1.515(lit.)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: ETHYL ALPHA-CHLOROPHENYLACETATE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL ALPHA-CHLOROPHENYLACETATE(4773-33-5)
• EPA Substance Registry System: ETHYL ALPHA-CHLOROPHENYLACETATE(4773-33-5)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-37/39-45
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• Hazardous Substances Data: 4773-33-5(Hazardous Substances Data)

Usage

Synthesis Reference(s)

Journal of the American Chemical Society, 70, p. 3626, 1948 DOI: 10.1021/ja01191a026Organic Syntheses, Coll. Vol. 4, p. 169, 1963

InChI:InChI=1/C10H11ClO2/c1-2-13-10(12)9(11)8-6-4-3-5-7-8/h3-7,9H,2H2,1H3/t9-/m0/s1

Upstream product

• 64-17-5 ethanol 
• 4755-72-0 Chloro-phenyl-acetic acid 
• 2912-62-1 α-chlorophenylacetyl chloride 
• 7719-09-7 thionyl chloride 
• 60-29-7 diethyl ether 
• 611-71-2 MANDELIC ACID 
• 50916-31-9 2-hydroxy-2-phenylacetyl chloride 
• 101-97-3 Ethyl 2-phenylethanoate 
• 121-44-8 triethylamine 
• 774-40-3 hydroxy-phenyl-acetic acid ethyl ester 
• 5317-66-8 ethyl α,α-dichlorophenylacetate 

Downstream Products

• 58007-81-1 dimethylthiocarbamoylsulfanyl-phenyl-acetic acid 
• 33224-94-1 butoxy-phenyl-acetic acid 
• 96-09-3 styrene oxide 
• 4755-72-0 Chloro-phenyl-acetic acid 
• 1004-99-5 2-chloro-2-phenylethanol 
• 101450-09-3 (2-diethylamino-ethoxy)-phenyl-acetic acid ethyl ester 
• 95770-77-7 4-phenyl-hexahydro-pyrido[2,1-c][1,4]oxazin-3-one 
• 95770-79-9 3-phenyl-hexahydro-pyrido[2,1-c][1,4]oxazin-4-one 
• 90915-12-1 2-imino-3-methyl-5-phenyl-thiazolidin-4-one 
• 2933-32-6 2-(methylamino)-5-phenyl-1,3-thiazol-4(5H)-one 
• 36387-87-8 2-anilino-5-phenyl-thiazol-4-one 
• 736-88-9 cis-1,2-Diphenylcyclopropane-1,2-dicarboxylic acid 
• 745-01-7 cis-1,2-Diphenyl-cyclopropan-dicarbonsaeure-(1,2)-diaethylester 
• 108207-46-1 (4-Methyl-6-oxo-1,6-dihydro-pyrimidin-2-ylsulfanyl)-phenyl-acetic acid ethyl ester 

Relevant articles and documents

Efficient α-chlorination of carbonyl containing compounds under basic conditions using methyl chlorosulfate

An efficient method for the α-chlorination of ketones under basic conditions is described using methyl chlorosulfate. Its applicability for the chlorination of other functional groups has also been studied and it is equally useful for the synthesis of α-chloroesters and amides. Methyl chlorosulfate is described for the first time as a positive chlorine source. Some aldol reactions which occur during the chlorination of some substrates are also reported.

SUBSTITUTED PHENYLLUREAS AND PHENYLAMIDES AS VANILLOID RECEPTOR LIGANDS

The invention relates to substituted phenylureas and phenylamides of formula (I), to processes for the preparation thereof, to pharmaceutical compositions containing these compounds and also to the use of these compounds for preparing pharmaceutical compositions.

Enzymatic hydrolysis and selective racemisation reactions of α-chloro esters

The kinetic resolution of α-chloro esters was effected with good selectivity using CLEC (Cross-Linked Enzyme Crystals) enzymes. The selective racemisation of α-chloro esters in the presence of α-chloro acids enabled a successful dynamic kinetic resolution reaction to be performed.