477712-01-9Relevant academic research and scientific papers
Design, syntheses and antitumor activities evaluation of 1,5-diaryl substituted pyrazole secnidazole ester derivatives
Teng, Qing-Hu,Sun, Gui-Xia,Luo, Shu-Ying,Wang, Kai,Liang, Fu-Pei
supporting information, p. 1656 - 1664 (2021/05/29)
According to the drug hybridization principle, a series of novel 1,5-diaryl substituted pyrazole secnidazole ester derivatives (6aa–6gc) have been synthesized by the combinations of various 1,5-diarylpyrazole-3-carboxylic acids with secnidazole. The in vi
Structure–activity relationship studies of 3-substituted pyrazoles as novel allosteric inhibitors of MALT1 protease
Asaba, Ken Nunettsu,Adachi, Yohei,Tokumaru, Kazuyuki,Watanabe, Akira,Goto, Yasufumi,Aoki, Takumi
, (2021/04/27)
We report the discovery of a novel series of 1,5-bisphenylpyrazoles as potent MALT1 inhibitors. Structure–activity relationship exploration of a hit compound led to a potent MALT1 inhibitor. Compound 33 showed strong activity against MALT1 (IC50/sub
