477721-53-2

Basic information

• Product Name: Benzoic acid, 4-[[[4-hydroxy-1-(phenylmethyl)-4-piperidinyl]methyl]methylamino]-, methyl ester
• CAS NO: 477721-53-2
• Molecular Formula: C22H28N2O3
• Molecular Weight: 368.476
• Mol File: 477721-53-2.mol

Chemical Properties

• CAS DataBase Reference: Benzoic acid, 4-[[[4-hydroxy-1-(phenylmethyl)-4-piperidinyl]methyl]methylamino]-, methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Benzoic acid, 4-[[[4-hydroxy-1-(phenylmethyl)-4-piperidinyl]methyl]methylamino]-, methyl ester(477721-53-2)
• EPA Substance Registry System: Benzoic acid, 4-[[[4-hydroxy-1-(phenylmethyl)-4-piperidinyl]methyl]methylamino]-, methyl ester(477721-53-2)

Safety Data

• Hazardous Substances Data: 477721-53-2(Hazardous Substances Data)

Upstream product

• 19867-34-6 N-benzyl-1-oxa-6-azaspiro[2,5]-octane 
• 53405-05-3 N-formyl p-aminobenzoic acid methyl ester 
• 13292-87-0 dimethyl sulfide borane 

Downstream Products

• 477721-55-4 methyl 4-[(4-hydroxypiperidin-4-ylmethyl)methylamino]-benzoate 

Relevant articles and documents

THERAPEUTIC AGENT FOR RESPIRATORY DISEASE CONTAINING 4-HYDROXYPIPERIDINE DERIVATIVE AS ACTIVE INGREDIENT

An agent for preventing/treating respiratory diseases contains, as an active ingredient, a compound represented by following Formula (I): wherein A is a group represented by L-W [wherein L is a bond or CH2; and W is O, SOn (wherein n is 0 to 2), or -NR7-(wherein R7 is hydrogen or lower alkyl)]; each of G1 and G2 is (CH2)r (wherein r is 0 to 2), provided that when n is 1, G1 and G2 may be bridged by lower alkylene; Y is a lower alkylene or (substituted) benzylidene; Z is a bond or O, provided that when Z is a bond, Y may form a 5- or 6-membered ring with carbon on the benzene ring; R1 is, for example, NO2, a lower alkoxycarbonyl, (substituted) carbamoyl, (protected) hydroxyl group, (protected) carboxyl, or (protected) N-hydroxycarbamoyl; each of R2and R3 is hydrogen, halogen, (halogenated) lower alkyl, (halogenated) lower alkoxy or NO2; each of R4 and R5 is, for example, hydrogen, halogen, (halogenated) lower alkyl, (halogenated) lower alkoxy, CN, or lower alkylsulfonyl; and R6 is hydrogen or lower alkyl, a salt thereof or a solvate of them. It has excellent antitussive activity when used as an agent for preventing/treating respiratory diseases such as lung cancer, common cold syndrome, pulmonary tuberculosis, pneumonia, acute bronchitis or chronic bronchitis.

4-HYDROXPIPERIDINE DERIVATIVE WITH ANALGETIC ACTIVITY

A compound represented by the following Formula (I): (wherein A represents oxygen atom or -NR3- (R3 represents hydrogen atom or lower alkyl group); R1 represents nitro group, lower alkoxycarbonyl group, carbamoyl group unsubstituted or mono- or di-substituted by lower alkyl group, unprotected or protected hydroxyl group, unprotected or protected carboxyl group, lower alkyl group substituted by unprotected or protected hydroxyl group, or tetrazolyl group; and R2 represents hydrogen atom, cyano group or lower alkylsulfonyl group, provided that when A is - NR3-, it is excluded that R1 represents unprotected or protected hydroxyl group or lower alkyl group substituted by unprotected or protected hydroxyl group) or its salt, and method for producing the compound, and a pharmaceutical composition containing the compound as active ingredient.