477788-91-3

Usage

Chemical structure

Contains a piperazine ring and a spiro ring, along with phenyl and propyl groups.

Potential applications

May have potential applications in pharmacology, as piperazine derivatives are commonly found in pharmaceutical drugs.

Further research

Necessary to fully understand the properties and potential applications of 1-Piperazineethanamine, N-1,4-dioxaspiro[4.5]dec-8-yl-4-phenyl-N-propyl-.

Upstream product

• 106-94-5 propyl bromide 
• 477788-90-2 (1,4-dioxa-spiro[4,5]dec-8-yl)-[2-(4-phenyl-piperazin-1-yl)-ethyl]-amine 
• 75000-24-7 2-[2-(4-phenylpiperazin-1-yl)ethyl]-1H-isoindole-1,3(2H)-dione 
• 21091-61-2 2-(4-phenyl-piperazin-1-yl)-ethylamine 
• 92-54-6 4-phenyl-1-piperazine 

Downstream Products

• 477789-22-3 N⁶-(2-(4-phenylpiperazin-1-yl)-ethyl)-N⁶-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine 
• 477788-92-4 4-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-propyl-amino}-cyclohexanone 

Relevant academic research and scientific papers

Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl] propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: Identification of highly potent and selective agonists for dopamine D3 receptor with potent in vivo activity

In the current report, we extend the SAR study on our hybrid structure 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen- 2-ol further to include heterocyclic bioisosteric analogues. Binding assays were carried out with HEK-29

Synthesis and biological characterization of novel hybrid 7-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro- naphthalen-2-ol and their heterocyclic bioisosteric analogues for dopamine D2 and D3 receptors

In a recent preliminary communication we described the development of a series of hybrid molecules for the dopamine D2 and D3 receptor subtypes. The design of these compounds was based on combining pharmacophoric elements of aminotetralin and piperazine m

Hybrid 2-aminotetralin and aryl-substituted piperazine compounds and their use in altering cns activity

Hybrid compounds containing in aminotetralin moiety or a heterocyclic and/or open chain analog thereof linked through an alkylene group to an aryl ring system-substituted piperidiene moiety exhibit high levels of CNS activity, in some cases exhibiting especially high relative binding efficiencies between D3 and D2 dopaminergic receptor subtypes.