477788-90-2

Upstream product

• 4746-97-8 cyclohexanedione monoethylene ketal 
• 21091-61-2 2-(4-phenyl-piperazin-1-yl)-ethylamine 
• 75000-24-7 2-[2-(4-phenylpiperazin-1-yl)ethyl]-1H-isoindole-1,3(2H)-dione 
• 92-54-6 4-phenyl-1-piperazine 

Downstream Products

• 477789-22-3 N⁶-(2-(4-phenylpiperazin-1-yl)-ethyl)-N⁶-propyl-4,5,6,7-tetrahydrobenzo[d]thiazole-2,6-diamine 
• 477788-92-4 4-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-propyl-amino}-cyclohexanone 
• 477788-91-3 (1,4-dioxa-spiro[4,5]dec-8-yl)-[2-(4-phenyl-piperazin-1-yl)-ethyl]-propyl-amine 

Relevant academic research and scientific papers

Bioisosteric heterocyclic versions of 7-{[2-(4-phenyl-piperazin-1-yl)ethyl] propylamino}-5,6,7,8-tetrahydronaphthalen-2-ol: Identification of highly potent and selective agonists for dopamine D3 receptor with potent in vivo activity

In the current report, we extend the SAR study on our hybrid structure 7-{[2-(4-phenyl-piperazin-1-yl)ethyl]propylamino}-5,6,7,8-tetrahydronaphthalen- 2-ol further to include heterocyclic bioisosteric analogues. Binding assays were carried out with HEK-29

Synthesis and biological characterization of novel hybrid 7-{[2-(4-phenyl-piperazin-1-yl)-ethyl]-propyl-amino}-5,6,7,8-tetrahydro- naphthalen-2-ol and their heterocyclic bioisosteric analogues for dopamine D2 and D3 receptors

In a recent preliminary communication we described the development of a series of hybrid molecules for the dopamine D2 and D3 receptor subtypes. The design of these compounds was based on combining pharmacophoric elements of aminotetralin and piperazine m

Hybrid 2-aminotetralin and aryl-substituted piperazine compounds and their use in altering cns activity

Hybrid compounds containing in aminotetralin moiety or a heterocyclic and/or open chain analog thereof linked through an alkylene group to an aryl ring system-substituted piperidiene moiety exhibit high levels of CNS activity, in some cases exhibiting especially high relative binding efficiencies between D3 and D2 dopaminergic receptor subtypes.