4778-86-3

Upstream product

• 108-42-9 3-chloro-aniline 
• 643-79-8 o-phthalic dicarboxaldehyde 
• 1234559-98-8 C₂₁H₁₅BrClNO₃ 
• 87-41-2 2-benzofuran-1(3H)-one 
• 119-67-5 o-carboxybenzaldehyde 
• 933-88-0 ortho-toluoyl chloride 
• 10449-88-4 N-(3-chlorophenyl)-2-methylbenzamide 
• 53474-45-6 [2-(3-chloro-phenyl)-4-oxo-1,2,3,4-tetrahydro-phthalazin-1-yl]-acetic acid 

Downstream Products

• 1234560-09-8 C₂₂H₁₇NO 
• 1234560-08-7 C₂₀H₁₅NO 

Relevant academic research and scientific papers

Hantzsch ester triggered metal-free cascade approach to isoindolinones

Disclosed herein is an expedient synthesis of biologically important isoindolinone derivatives from reactions of 2-formylbenzoic acids with various amines. This method operates via a deliberately designed catalyst-free tandem reductive amination/cyclization cascade event triggered by a transfer hydrogenation process with easily available Hantzsch ester as the organic hydride source. The ease of operation, mild reaction conditions, facile accessibility of the starting materials, and easy scalability of the current method distinguish it from the other precedent protocols, thus enable it a practical approach to the syntheses of valuable isoindolinone-incorporated drugs.

Phthalimidine synthesis via the direct condensation between phthalide and primary amine in the presence of catalytic amount of InCl3

Background: We previously reported the 1:1 condensation reaction between ophthalaldehyde and primary amine in the presence of 1,2,3-1H-benzotriazole and 2-mercaptoethanol as dual synthetic auxiliaries to provide phthalimidines (2,3-dihydroisoindol-1-ones) under mild reaction conditions in good isolated yields. However, this reaction was found to proceed via dissymmetrization of equi-oxidation stage functionalities (carbonyl groups herein), which would give rise to regioisomer(s) whenever the orientation of substituents in the target molecule phthalimidine was dissymmetrical. In order to overcome such defects, we focused on phthalide, which possessed identical electronic structure with that of target molecule phthalimidine. Thus, the condensation between a phthalide derivative and a primary amine would eliminate a water molecule, but does not accompany with any kind of redox paths. Therefore, dissymmetrical trends possessed by the phthalide derivative should transfer directly to the resulting phthalimidine, and as a result the formation of possible regioisomer(s) can completely be prevented. This strategy has existed as the oldest method of phthalimidine synthesis, however, Lewis acid catalysts utilized in the past were not appropriate to extend its scope. In this report, we demonstrate an improved method of phthalimidine synthesis along this line using InCl3 as a catalyst, which would allow the synthesis of this class to accommodate with the contemporary standard of organic syntheses. Method: In general, aniline (2.0 mmol, used at once as reagent and solvent) was added to the flask containing phthalide (1.0 mmol) and InCl3 (an appropriate amount) under Ar atmosphere over Ca. 3 min with stirring, and the whole mixture was heated at gentle reflux for an appropriate period. After usual work-up, crude products were purified by column chromatography on silica gel. Isolated components were ascertained by 1H NMR spectral comparison with the authentic samples prepared by our former methods. Results: Optimization of the reaction condition was explored using phthalide and aniline. Thus, decrement of yields occurred whenever amounts of InCl3 catalyst were reduced, however, longer reaction periods improved isolated yields every time. Even in the use of 1 mol% of InCl3 catalyst, reaction would complete within a few days. As a result, the direct condensation between phthalide and aniline with the use of a truly catalytic amount of Lewis acid catalyst was made possible for the first time in the history of phthalimidine syntheses. Extension of this strategy to some primary amines other than aniline was successful, too. Based on experimental results, our plausible mechanism was proposed, in which the reaction commenced by nucleophilic attack of an amino group towards 3-position of oxygen-chelated phthalide. Conclusion: We succeeded in the direct condensation reaction between phthalide and primary amine in the presence of a catalytic amount of Lewis acid catalyst, InCl3, for the first time. Although successful examples have thus far been limited to some combination that affords clear reaction mixtures (except for the catalyst) under high-temperature, solvent-free heating, we believe that we have attained a tacit basis to prepare a variety of phthalimidine derivatives possessing a variety of substituent patterns.

Application of the mild-condition phthalimidine synthesis with use of 1,2,3-1h-benzotriazole and 2-mercaptoethanol as dual synthetic auxiliaries. Effective synthesis of phthalimidines possessing a variety of substituents at 2-position

The mild-condition phthalimidine synthesis based on Mannich type 1:1 condensation reaction between o-phthalaldehyde with a variety of primary amines in the presence of excess 2-mercaptoethanol and 1,2,3-1H-benzotriazole as "dual synthetic auxiliaries" in MeCN for 13 h at room temperature afford 2-substituted phthalimidines (2,3-dihydroisoindol-1-one) in fair to good isolated yields.

Transition metal free intramolecular selective oxidative C(sp3)-N coupling: Synthesis of N-aryl-isoindolinones from 2-alkylbenzamides

A synthetic method has been developed for the preparation of biologically important isoindolinones including indoprofen and DWP205190 drugs from 2-alkylbenzamide substrates by transition metal-free intramolecular selective oxidative coupling of C(sp3)-H and N-H bonds utilizing iodine, potassium carbonate and di-tert-butyl peroxide in acetonitrile at 110-140 °C.

Synthesis of N -arylisoindolin-1-ones via pd-catalyzed intramolecular decarbonylative coupling of N -(2-bromobenzyl)oxanilic acid phenyl esters

Ethyl and phenyl oxanilates were readily prepared from N-(2-bromobenzyl) anilines and oxalyl chloride monoethyl and monophenyl esters, respectively. It was found that the ethyl oxanilate survived in the presence of K 2CO3 in DMA at 120°C and underwent an intramolecular direct arylation using Pd(OAc)2-dppf, furnishing the 5,6-dihydrophenanthridine derivative. In contrast, the corresponding phenyl oxanilates decomposed upon exposure to K2CO3 in DMA at 120 C and were transformed into N-arylisoindolin-1-ones via Pd(OAc) 2-dppf-catalyzed intramolecular decarbonylative coupling. Except for the 4-methoxy-substituted oxanilic acid phenyl ester, other phenyl oxanilates possessing electron-withdrawing (NO2, Cl) and weak electron-donating (Me) substituents provided the N-arylisoindolin-1-ones in 43-80% yields.

Recent progress of phthalimidine syntheses

Phthalimidine (2,3-dihydro-1H-isoindol-1-one) syntheses in recent years are reviewed primarily for those involving synthetic auxiliary-mediated mild Mannich type condensation reactions.