478169-68-5

Usage

Uses

Used in Organic Synthesis:
Methyl 3-hydroxy-4-((triMethylsilyl)ethynyl)benzoate is used as a building block in organic synthesis for its ability to contribute to the formation of more complex molecules. Its functional groups and unique structure make it a valuable component in the creation of advanced chemical compounds.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Methyl 3-hydroxy-4-((triMethylsilyl)ethynyl)benzoate is utilized as a key intermediate in the synthesis of various drugs. Its presence in the molecular structure can influence the pharmacological properties, such as solubility, stability, and bioavailability, which are critical for drug efficacy and safety.
Used in Agrochemical Industry:
Methyl 3-hydroxy-4-((triMethylsilyl)ethynyl)benzoate also finds application in the agrochemical sector, where it serves as a precursor in the development of pesticides and other agricultural chemicals. Its role in these compounds can enhance their effectiveness in protecting crops and improving yield.
Used in Fine Chemicals Production:
Methyl 3-hydroxy-4-((triMethylsilyl)ethynyl)benzoate is also used in the production of fine chemicals, which are high-purity chemicals used in various industries, including fragrances, flavors, and specialty chemicals. The unique properties of Methyl 3-hydroxy-4-((triMethylsilyl)ethynyl)benzoate contribute to the quality and performance of these fine chemicals.

Upstream product

• 157942-12-6 methyl 3-hydroxy-4-iodobenzoate 
• 1066-54-2 trimethylsilylacetylene 

Downstream Products

• 588703-29-1 methyl benzofuran-6-carboxylate 
• 77095-51-3 benzofuran-6-carboxylic acid 
• 501892-53-1 N-[(1S,2R,4R)-7-Azabicyclo[2.2.1]hept-2-yl]-1-benzofuran-6-carboxamide hydrochloride 
• 478169-69-6 methyl 3-hydroxy-4-acetyl-benzoate 

Relevant academic research and scientific papers

Synthesis method of 3-hydroxy-4-((trimethylsilyl) ethynyl) methyl benzoate

The invention relates to a synthetic method of 3-hydroxy-4-((trimethylsilyl) ethynyl) methyl benzoate, and belongs to the technical field of synthesis of medical intermediates. According to the method, 4-iodo-3-hydroxybenzoic acid and trimethylsilylacetyl

Discovery of N-[(3R)-1-azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5- carboxamide, an agonist of the α7 nicotinic acetylcholine receptor, for the potential treatment of cognitive deficits in schizophrenia: Synthesis and structure-activity relationship

N-[(3R)-1-Azabicyclo[2.2.2]oct-3-yl]furo[2,3-c]pyridine-5-carboxamide (14, PHA-543,613), a novel agonist of the α7 neuronal nicotinic acetylcholine receptor (α7 nAChR), has been identified as a potential treatment of cognitive deficits in schizophrenia. Compound 14 is a potent and selective a7 nAChR agonist with an excellent in vitro profile. The compound is characterized by rapid brain penetration and high oral bioavailability in rat and demonstrates in vivo efficacy in auditory sensory gating and, in an in vivo model to assess cognitive performance, novel object recognition.

Azabicyclic compounds for the treatment of disease

The invention provides compounds of Formula I: 1wherein Azabicyclo is 2These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful in pharmaceuticals in which α7 is known to be involved.

Quinuclidine-substituted hetero-bicyclic aromatic compounds for the treatment of disease

The invention provides compounds of Formula I: wherein W0 is a bicyclic moiety and is These compounds may be in the form of pharmaceutical salts or compositions, may be in pure enantiomeric form or racemic mixtures, and are useful to treat diseases or conditions in which α7 is known to be involved.

Substituted 7-aza[2.2.1]bicycloheptanes for the treatment of disease

The invention provides compounds of Formula I: which may be in the form of pharmaceutical acceptable salts or compositions, are useful in treating diseases or conditions in which α7 nicotinic acetylcholine receptors (nAChRs) are known to be involved.