Methyl 3-hydroxy-4-((triMethylsilyl)ethynyl)benzoate

Base Information

• Chemical Name: Methyl 3-hydroxy-4-((triMethylsilyl)ethynyl)benzoate
• CAS No.: 478169-68-5
• Molecular Formula: C13H16O3Si
• Molecular Weight: 248.354
• Mol file: 478169-68-5.mol

Synonyms:Methyl 3-hydroxy-4-((trimethylsilyl)ethynyl)benzoate;3-Hydroxy-4-trimethylsilanylethynyl-benzoic acid methyl ester;

Chemical Property of Methyl 3-hydroxy-4-((triMethylsilyl)ethynyl)benzoate

Chemical Property:

• Boiling Point: 332.2±42.0 °C(Predicted)
• PKA: 8.80±0.40(Predicted)
• PSA: 46.53000
• Density: 1.10±0.1 g/cm3(Predicted)
• LogP: 2.40770
• Storage Temp.: Inert atmosphere,Room Temperature

Purity/Quality:

97% ^*data from raw suppliers

Methyl3-hydroxy-4-((trimethylsilyl)ethynyl)benzoate 98% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of Methyl 3-hydroxy-4-((triMethylsilyl)ethynyl)benzoate

There total 1 articles about Methyl 3-hydroxy-4-((triMethylsilyl)ethynyl)benzoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.5%

methyl 3-hydroxy-4-iodobenzoate (157942-12-6) + trimethylsilylacetylene (1066-54-2) → methyl 3-hydroxy-4-[(trimethylsilyl)ethynyl]benzoate (478169-68-5)

Guidance literature:

With copper(l) iodide; N,N,N,N,-tetramethylethylenediamine; diethylamine; triphenylphosphine; In toluene; at 20 - 27 ℃; for 1h; Inert atmosphere;

Reference yield: 93.0%

methyl 3-hydroxy-4-[(trimethylsilyl)ethynyl]benzoate (478169-68-5) + methanol (67-56-1) → benzofuran-6-carboxylic acid (77095-51-3)

Guidance literature:

methyl 3-hydroxy-4-[(trimethylsilyl)ethynyl]benzoate; With copper(l) iodide; triethylamine; In ethanol; at 75 ℃; for 3h;

methanol; With pyrographite; In ethanol; for 1h; Heating / reflux;

With sodium hydroxide; In ethanol; at 20 ℃;

Reference yield: 70.0%

methyl 3-hydroxy-4-[(trimethylsilyl)ethynyl]benzoate (478169-68-5) + methanol (67-56-1) → methyl benzofuran-6-carboxylate (588703-29-1)

Guidance literature:

methyl 3-hydroxy-4-[(trimethylsilyl)ethynyl]benzoate; With copper(l) iodide; In methanol; at 75 ℃; for 3h;

methanol; With pyrographite; In methanol; at 20 - 95 ℃;

With sodium hydroxide; In ethanol; at 20 ℃;

upstream raw materials:

methyl 3-hydroxy-4-iodobenzoate

trimethylsilylacetylene

Downstream raw materials:

methyl benzofuran-6-carboxylate

benzofuran-6-carboxylic acid

N-[(1S,2R,4R)-7-Azabicyclo[2.2.1]hept-2-yl]-1-benzofuran-6-carboxamide hydrochloride

methyl 3-hydroxy-4-acetyl-benzoate

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