478289-62-2Relevant academic research and scientific papers
Combined Alkylating Agents as a Resolution for Highly Selective N-Alkylation of 2-Hydroxybenzaldehyde Acylhydrazones
Cheng, Xin J.,Jin, Long F.,Wu, La M.,Zhang, Hui J.,Zhang, Qiao Y.,Zhao, Xin Y.
supporting information, p. 1334 - 1338 (2019/06/19)
Although 2-hydroxybenzaldehyde acylhydrazones, such as salicylaldehyde acylhydrazones, are intriguing bioactive molecules, few of their N-alkylated derivatives are known, and only methyl analogues have been reported previously. We achieved selective N-alk
N-2-Hydroxybenzaldehyde acylhydrazone-Fe(iii) complex: Synthesis, crystal structure and its efficient and selective N-methylation
Li, Zhiyou,Wu, Lamei,Zhang, Tao,Huang, Zhengxi,Qiu, Guofu,Zhou, Zhongqiang,Jin, Longfei
supporting information, p. 7554 - 7560 (2014/05/20)
N-Methyl-N′-2-hydroxybenzaldehyde acylhydrazones have been chemospecifically synthesized in good yield by N-methylation of the Fe(iii) complexes of N-2-hydroxybenzaldehyde acylhydrazones with methyl iodide in tetrahydrofuran. The reaction proceeds with the exclusive formation of the N-methyl derivative without any concurrent O-methylation side reactions. In addition, the N-methylation reaction occurred simultaneously with a complete deprotection step (elimination of the metal ion). As a result, the N-methyl product was obtained in excellent purity without time-consuming chromatographic workup. A free N-2-hydroxybenzaldehyde acylhydrazone ligand could not be methylated under the same conditions. This journal is the Partner Organisations 2014.
