4789-09-7

Basic information

• Product Name: 1-PHENYL-PIPERIDIN-2-ONE
• Synonyms: 1-PHENYL-PIPERIDIN-2-ONE;1-(Phenyl)-2-piperidone;1-Phenyl-2-piperidone;1-Phenyl-2-piperidinone;N-Phenyl-2-piperidinone;2-Piperidinone, 1-phenyl-
• CAS NO: 4789-09-7
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.22702
• Mol File: 4789-09-7.mol
• Article Data: 26

Chemical Properties

• Melting Point: 99-100℃
• Appearance: /
• Density: 1.107
• CAS DataBase Reference: 1-PHENYL-PIPERIDIN-2-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-PHENYL-PIPERIDIN-2-ONE(4789-09-7)
• EPA Substance Registry System: 1-PHENYL-PIPERIDIN-2-ONE(4789-09-7)

Safety Data

• Hazardous Substances Data: 4789-09-7(Hazardous Substances Data)

Usage

General Description

1-PHENYL-PIPERIDIN-2-ONE, also known as PPA or α-phenyl-piperidin-2-one, is a chemical compound with the molecular formula C13H15NO. It is a white crystalline powder that is commonly used as a precursor in the synthesis of various pharmaceutical drugs, including fentanyl and its derivatives. PPA is also a key intermediate in the production of a range of psychoactive substances and has gained notoriety as a synthetic opioid precursor frequently used in illegal drug manufacturing. Due to its potential for abuse and association with illicit drug production, 1-PHENYL-PIPERIDIN-2-ONE is a controlled substance in many countries and subject to strict regulations.

Upstream product

• 79-21-0 peracetic acid 
• 13683-42-6 N-(cyclopentylidene)aniline 
• 7661-20-3 N-5-bromovaleryl-aniline 
• 675-20-7 piperidin-2-one 
• 108-86-1 bromobenzene 
• 91247-37-9 δ-Hydroxy-valeranilid 
• 142-71-2 copper diacetate 
• 603-33-8 triphenylbismuthane 
• 147-85-3 L-proline 
• 146500-37-0 methyl 1-phenyl-2-pyrrolidinecarboxylate 
• 542-28-9 3,4,5,6-tetrahydro-2H-pyran-2-one 
• 62-53-3 aniline 
• 108-90-7 chlorobenzene 
• 1575-61-7 5-Chlorovaleroyl chloride 

Downstream Products

• 54104-93-7 1-phenyl-1,3,4,4a,5,6,7,8,12b-decahydro-2H-1,8a-diaza-triphenylene 
• 847910-89-8 (2,8-diphenyl-5,6,7,8-tetrahydro-pyrido[2,3-d]pyrimidin-4-yl)-dimethyl-amine 
• 129435-79-6 5,6-dihydro-2-oxo-3-(2-oxopropyl)-1-phenyl-3-piperine 
• 129435-78-5 (E)-3-(2-oxopropylidene)-1-phenylpiperidin-2-one 
• 129451-28-1 (E)-3-(2,2-ethylenedioxypropylidene)-1-phenylpiperidin-2-one 
• 129435-74-1 (R*)-3-<(S*)-2,2-(ethylenedioxy)-1-hydroxypropyl>-1-phenylpiperidin-2-one 
• 129435-74-1 (R*)-3-<(R*)-2,2-(ethylenedioxy)-1-hydroxypropyl>-1-phenylpiperidin-2-one 
• 129435-76-3 (R*)-3-<(S*)-2,2-(ethylenedioxy)-1-methylsulfonyloxy>-1-phenylpiperidin-2-one 
• 129435-76-3 (R*)-3-<(R*)-2,2-(ethylenedioxy)-1-methylsulfonyloxy>-1-phenylpiperidin-2-one 

Relevant articles and documents

Enantioconvergent Alkylations of Amines by Alkyl Electrophiles: Copper-Catalyzed Nucleophilic Substitutions of Racemic α-Halolactams by Indoles

Transition-metal catalysis has the potential to address shortcomings in the classic SN2 reaction of an amine with an alkyl electrophile, both with respect to reactivity and to enantioselectivity. In this study, we describe the development of a user-friendly method (reaction at room temperature, with commercially available catalyst components) for the enantioconvergent nucleophilic substitution of racemic secondary alkyl halides (α-iodolactams) by indoles. Mechanistic studies are consistent with the formation of a copper(I)-indolyl complex that reacts at different rates with the two enantiomers of the electrophile, which interconvert under the reaction conditions (dynamic kinetic resolution). This investigation complements earlier work on photoinduced enantioconvergent N-alkylation, supporting the premise that this important challenge can be addressed by a range of strategies.

Ruthenium-Pincer-Catalyzed Hydrogenation of Lactams to Amino Alcohols

By using the commercially available ruthenium pincer complex (Ru-MACHO-BH) as a catalyst, the challenging direct hydrogenation of lactams and analogues has been successfully accomplished to deliver corresponding value-added amino alcohols in good-to-excellent yields under mild reaction conditions. Remarkably, in addition to N-protected lactams, unprotected ones could also be readily reduced in the presence of a catalytic amount of weak base or even under neutral reaction conditions, which further highlights the broad substrate scope and the protocol efficiency.

PROCESS FOR THE PREPARATION OF APIXABAN AND INTERMEDIATES THEREOF

The present invention refers to novel process for the preparation of Apixaban. Further, the invention also related to a process for the preparation of intermediate of Apixaban from very basic and cheap row material i.e. Aniline which is widely commercially available. The present invention provides process for preparation of Apixaban using a different sequence of synthetic steps and does not involve use of Ullmann reaction.