478911-64-7

Basic information

• Product Name: (R)-2-{(S)-3-Methyl-3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-1-yl}-propionic acid methyl ester
• Synonyms: (R)-2-{(S)-3-Methyl-3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-1-yl}-propionic acid methyl ester
• CAS NO: 478911-64-7
• Molecular Weight: 432.519
• Mol File: 478911-64-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (R)-2-{(S)-3-Methyl-3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-1-yl}-propionic acid methyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-2-{(S)-3-Methyl-3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-1-yl}-propionic acid methyl ester(478911-64-7)
• EPA Substance Registry System: (R)-2-{(S)-3-Methyl-3-[4-(2-methyl-quinolin-4-ylmethoxy)-phenyl]-2-oxo-pyrrolidin-1-yl}-propionic acid methyl ester(478911-64-7)

Safety Data

• Hazardous Substances Data: 478911-64-7(Hazardous Substances Data)

Upstream product

• 223406-02-8 methyl (2R)-2-{(3S)-3-[4-(benzyloxy)phenyl]-3-methyl-2-oxo-1-pyrrolidinyl}propanoate 
• 223405-99-0 2-(4-benzyloxy-phenyl)-2-methyl-pent-4-enoic acid methyl ester 
• 223406-00-6 methyl 2-[4-(benzyloxy)phenyl]-2-methyl-4-oxobutanoate 
• 89618-33-7 methyl 2-(4-benzyloxyphenyl)propionate 
• 68641-16-7 (4-benzyloxy-phenyl)-acetic acid methyl ester 
• 478911-32-9 methyl (2R)-2-[(3S)-3-(4-hydroxyphenyl)-3-methyl-2-oxo-1-pyrrolidinyl]propanoate 

Relevant articles and documents

Discovery of γ-lactam hydroxamic acids as selective inhibitors of tumor necrosis factor α converting enzyme: Design, synthesis, and structure-activity relationships

New γ-lactam TACE inhibitors were designed from known MMP inhibitors. A homology model of TACE was built and examined to identify the S1′ site as the key area for TACE selectivity over MMPs. Rational exploration of the P1′-S1′ interactions resulted in the discovery of the 3,5-disubstituted benzyl ether as a TACE-selective P1′ group. Further optimization led to the discovery of IK682 as a selective and orally bioavailable TACE inhibitor.