478958-03-1Relevant articles and documents
Improving the oral efficacy of CNS drug candidates: Discovery of highly orally efficacious piperidinyl piperidine M2 muscarinic receptor antagonists
Wang, Yuguang,Chackalamannil, Samuel,Hu, Zhiyong,Greenlee, William J.,Clader, John,Boyle, Craig D.,Kaminski, James J.,Billard, William,Binch III, Herbert,Crosby, Gordon,Ruperto, Vilma,Duffy, Ruth A.,Cohen-Williams, Mary,Coffin, Vicki L.,Cox, Kathleen A.,Grotz, Diane E.,Lachowicz, Jean E.
, p. 5415 - 5418 (2007/10/03)
In search of a backup M2 muscarinic receptor antagonist to the previously reported compound 1, we discovered compound (+)-14, which showed superior oral efficacy in animal models. The improvement of oral efficacy was achieved by modulating both