4792-60-3

Usage

Uses

Used in Organic Synthesis:
4-(Benzyloxy)-2-methylaniline is used as a key intermediate in organic synthesis for the production of various chemical compounds. Its unique structure allows for versatile reactions and transformations, making it a valuable component in the synthesis of complex organic molecules.
Used in Pharmaceutical Development:
In the pharmaceutical industry, 4-(Benzyloxy)-2-methylaniline is utilized as a building block for the preparation of various drugs. Its presence in the molecular structure can contribute to the desired pharmacological properties, such as potency, selectivity, and bioavailability, ultimately leading to the development of effective therapeutic agents.
Used in Agrochemical Production:
4-(Benzyloxy)-2-methylaniline also finds application in the agrochemical sector, where it serves as a precursor for the synthesis of various agrochemicals, including pesticides and herbicides. Its incorporation into these compounds can enhance their efficacy in controlling pests and weeds, thereby contributing to improved crop yields and agricultural productivity.
Used in Research and Development:
In the fields of chemistry and material science, 4-(Benzyloxy)-2-methylaniline is employed as a research compound to explore new reactions, mechanisms, and properties. Its unique structure and reactivity make it an attractive candidate for studying novel chemical transformations and developing innovative materials with potential applications in various industries.
It is crucial to note that the use of 4-(Benzyloxy)-2-methylaniline in these applications must be accompanied by proper safety measures and environmental considerations to minimize any potential hazards associated with its handling and disposal.

Upstream product

• 61433-76-9 4'-(benzyloxy)-o-acetotoluidide 
• 2835-99-6 4-amino-3-methylphenol 
• 100-39-0 benzyl bromide 
• 17671-75-9 4-(benzyloxy)-1-bromo-2-methylbenzene 
• 39495-15-3 4-acetamido-3-methylphenol 
• 2581-34-2 3-methyl-4-nitrophenol 
• 22424-58-4 5-benzyloxy-2-nitrotoluene 

Downstream Products

• 196616-55-4 5-Benzyloxy-3,7-dimethyl-1H-indole-2-carboxylic acid methyl ester 
• 196616-42-9 3,7-Dimethyl-1H-indole-4,5-dione 
• 196616-57-6 5-Benzyloxy-3,7-dimethyl-1H-indole 
• 196616-56-5 2-carboxy-3,7-dimethyl-5-benzyloxyindole 
• 220854-55-7 1-(2-methyl-4-benzyloxyphenyl)-4-oxo-6-β,β,β-trifluoroethoxy-2,3,4,5-tetrahydropyrrolo[3,2-c]quinoline 
• 1096162-12-7 C₃₂H₃₂N₂O₄ 
• 1096162-11-6 C₂₈H₃₂N₂O₄ 
• 568596-29-2 1-(5-benzyloxyindazol-1-yl)ethanone 
• 417724-34-6 N-methyl-4-benzyloxy-2-methylaniline 
• 164861-28-3 1-[4-(4-Benzyloxy-2-methyl-phenylamino)-8-hydroxy-quinolin-3-yl]-butan-1-one 

Relevant academic research and scientific papers

Microwave-assisted reduction of aromatic nitro compounds with novel oxo-rhenium complexes

The reduction of several aromatic nitro compounds to amines by means of the two novel catalytic systems ([IMes]2ReOBr3)/PhSiH3 and ([Py]3ReNOBr2)/PhSiH3 under microwave irradiation is here reported. These two systems were able to perform the reduction of nitro groups with higher TON and TOF when compared with previously reported systems based on oxo-rhenium core under standard heating, although they showed a lesser broad reaction scope compared with the known systems.

COMPOUNDS, COMPOSITIONS, AND METHODS FOR MODULATING CFTR

The present disclosure is directed to disclosed compounds that modulate, e.g., address underlying defects in cellular processing of CFTR activity.

Palladium-catalyzed amination of aryl chlorides and bromides with ammonium salts

We report the palladium-catalyzed coupling of aryl halides with ammonia and gaseous amines as their ammonium salts. The coupling of aryl chlorides and ortho-substituted aryl bromides with ammonium sulfate forms anilines with higher selectivity for the primary arylamine over the diarylamine than couplings with ammonia in dioxane. The resting state for the reactions of aryl chlorides is different from the resting state for the reactions of aryl bromides, and this change in resting states is proposed to account for a difference in selectivities for reactions of the two haloarenes.

Pinacol as a new green reducing agent: Molybdenum-catalyzed chemoselective reduction of sulfoxides and nitroaromatics

Pinacol is disclosed as a new chemoselective and environmentally benign reducing agent for sulfoxides and nitroaromatics assisted by readily available dichlorodioxomolybdenum(VI) complexes as catalysts. A wide range of substrates including those bearing challenging functional groups has been efficiently and selectively reduced with acetone and water being the only by-products of these reactions. Copyright

Novel organophosphorus derivatives of indazoles and use thereof as medicinal products

The present invention relates in particular to novel chemical compounds, particularly to novel organophosphorus derivatives of indazoles, to the compositions containing them, and to the use thereof as medicinal products for treating cancers.

Nitrogen-containing aromatic derivatives

Compounds represented by the following general formula: [wherein Ag is an optionally substituted 5- to 14-membered heterocyclic group, etc.; Xg is —O—, —S—, etc.; Yg is an optionally substituted C6-14 aryl group, an optionally substituted 5- to 14-membered heterocyclic group, etc.; and Tg1 is a group represented by the following general formula: (wherein Eg is a single bond or —N(Rg2)—, Rg1 and Rg2 each independently represent a hydrogen atom, an optionally substituted C1-6 alkyl group, etc. and Zg represents a C1-8 alkyl group, a C3-8 alicyclic hydrocarbon group, a C6-14 aryl group, etc.)], salts thereof or hydrates of the foregoing.

Novel 6-substituted uracil analogs as inhibitors of the angiogenic actions of thymidine phosphorylase

Thymidine phosphorylase (TP) catalyzes the reversible phosphorolysis of thymidine and other pyrimidine 2′-deoxyribonucleosides. In addition, TP has been shown to possess angiogenic activity in a number of in vitro and in vivo assays, and its angiogenic activity has been linked to its catalytic activity. A series of 5- and 6-substituted uracil derivatives were synthesized and evaluated for their abilities to inhibit TP activity. Among the most active compounds was a 6-amino-substituted uracil analog, 6-(2-aminoethyl)amino-5-chlorouracil (AEAC), which was a competitive inhibitor with a Ki of 165 nM. The inhibitory activity of AEAC was selective for TP, as it did not inhibit purine nucleoside phosphorylase or uridine phosphorylase at concentrations up to 1 mM. Human recombinant TP induced human umbilical vein endothelial cell (HUVEC) migration in a modified Boyden chamber assay in vitro, and this action could be abrogated by the TP inhibitors. The actions of the inhibitors were specific for TP, as they had no effect on the chemotactic actions of vascular endothelial growth factor (VEGF). HUVEC migration was also induced when TP-transfected human colon and breast carcinoma cells were co-cultured in the Boyden chamber assay in place of the purified angiogenic factors, and a TP inhibitor blocked the tumor cell-mediated migration almost completely. These studies suggest that inhibitors of TP may be useful in pathological conditions that are dependent upon TP-driven angiogenesis.

Synthesis, physicochemical properties, and amide-oxidation reaction of indolequinone derivatives as model compounds of novel organic cofactor TTQ of amine dehydrogenases

3,4-Disubstituted 6,7-indolequinones [1,3-dimethyl]-4-(3'-methylindol- 2'-yl)indole-6,7-dione (2), 3-methyl-4-phenylindole-6,7-dione (3), and 3,4- dimethyl-6,7-dione (4)] and a 3,7-disubstituted 4,5-indolequinone [3,7- dimethylindole-4,5-dione (5)] have been synthesized as models for the novel organic cofactor TTQ bacterial amine dehydrogenases. The substituent and structural effects on the physicochemical properties of the quinones have been investigated in detail by comparing the spectroscopic data (UV-vis, IR, 1H- and 13C-NMR), pK(a) values of the pyrrole proton, and the two-electron redox potentials with those of model compound 1 [3-methyl-4-(3'-methylindol- 2'-yl)indole-6,7-dione] previously reported (ref 5). Reactivity of each quinone in the transamination process [iminoquinone formation (k1), rearrangement to product-imine (k2) and aminophenol formation (k3)] has been investigated kinetically, revealing that the substituent and structural effects on the amine-oxidation reaction are not significant. In the aerobic catalytic oxidation of benzylamine, however, the aromatic substituents on the quinone ring play an important role to protect the quinone from the deactivation process of a Michael-type addition by the amine, making it act as an efficient turnover catalyst.

Derivatives of 2-substituted-hydroxyanilino-hexahydro-2H-benzo[α]quinolizines

2-Substituted-hydroxyanilino-hexahydro-2H-benzo[α]quinolizines of the structural formula, SPC1 In which R1 is a hydrogen atom or an alkanoyl group of 2 to 4 carbon atoms and each of substituents R2, R3, R4, R5, and R6 is a hydrogen atom, a hydroxyl, or a methyl group, such that at least one of the latter substituents is a hydroxyl group, exhibit coronary vasodilating activity.