479206-75-2Relevant academic research and scientific papers
Reactivity trends in the reaction of alkynes with 3-oxo-camphorsulfonylimine
Santos, A. Mafalda,Carvalho, M. Fernanda N. N.,Galv?o, Adelino M.,Pombeiro, Armando J. L.
, p. 691 - 698 (2002)
The regioselective addition of deprotonated alkynes (phenyl-1-propyne, propargyl ether or tetrahydropyran-protected 3-butyn-1-ol) to the imine group was identified as a competitive process to the nucleophilic addition to the keto group of (1S)-3-oxo-camphorsulfonylimine. The selectivity of the process depends on the characteristics of the nucleophile and the reaction conditions. In the case of propargyl ether it was possible to render the imine addition the main process. The structural characterization of compounds 1, 2, 6 by X-ray diffraction analysis show that the C2-C3 bond becomes longer upon nucleophilic addition to the imine group of (1S)-3-oxo-camphorsulfonylimine. This trend is believed to favour the ring opening process that undergoes the formation of the spiro type compound 7.
Ring modifications in camphorimines purely organic or promoted by Pt(II)
Carvalho, M. Fernanda N. N.,Ferreira, Ana S. D.,Herrmann, Rudolf
, p. 2305 - 2313 (2013/07/26)
The reactivity of 3-oxo-camphorsulfonylimine (1) was explored toward the formation of new organic species in processes strictly organic or catalyzed by platinum. Synthesis and characterization of (1S)-1-[7,7-dimethyl-2-(4- ethinylphenylimino)-3-oxo-bicyclo [2.2.1]heptanyl]-methanesulfonamide (2), (3aS,7R)-7-hydroxy-8,8-dimethyl-7-(Nmethylamino-1-propynyl)-4,5,6, 7-tetrahydro-3H-3a,6-methano-2,1-benzisothiazole 2,2-dioxide (4a), (3aS,6aR,9aR)-8-benzyl-10,10-dimethyl-6a-hydroxy-9-(E-2-phenylethylidene)-3,3-a, 4,5,6,7-hexahydro-1H,9H-3a,6-methano-indeno[3a,4c]isothiazole 2,2-dioxide (6), and (2S, 3aS,6S)-9-benzyl-5,6-dihydro-11,11-dimethyl-10-phenylacetyl-3H-3a,6- methano-1H-yclonon [c]isothiazol-7(4H)-one 2-oxide (7) are reported as well as the activation of (1aS,3aS,7R)-7-hydroxy-1a,7-bis(3-phenyl-1-propynyl)-8,8- dimethyl-1,1a,4,5,6,7-hexahydro-3H-3a,6-methano-2,1-benzisothiazole 2,2-dioxide (3a) toward ring annulation or ring expansion by reaction with Pt(II) depending on the reaction conditions. Copyright
