479232-11-6Relevant academic research and scientific papers
One-step construction of unsymmetrical thioureas and oxazolidinethiones from amines and carbon disulfide: Via a cascade reaction sequence
Ding, Chaochao,Wang, Shaoli,Sheng, Yaoguang,Dai, Qian,Zhao, Yunjie,Liang, Guang,Song, Zengqiang
, p. 26768 - 26772 (2019/09/06)
A concise and versatile method for the construction of unsymmetrical thioureas and oxazolidinethiones from amines and carbon disulfide has been achieved in DMSO without addition of extra reagents. The present protocol is compatible with various secondary amines and primary amines, and suitable for intermolecular and intramolecular reactions. Diverse unsymmetrical thioureas and oxazolidinethiones were efficiently obtained in good to excellent yields via a cascade reaction sequence.
Preparation method of asymmetric thiourea compound
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Paragraph 0102-0106, (2019/10/23)
The invention discloses a preparation method of asymmetric thiourea compounds, and the method comprises the following steps: synthesizing the asymmetric thiourea compounds by taking amine compounds and carbon disulfide as substrates in a DMSO or DMF solvent. The method synthesizes the asymmetric thiourea compounds in one step through series reaction of three components. The reaction raw materialsare cheap and easily available, and the preparation method is simple. The reaction requires only the solvent, does not need other additives, has high yield and simple operation, and is suitable for the synthesis of different types of asymmetric thiourea compounds. The method can be used for synthesizing a series of asymmetric thiourea compounds, and the synthesized products can not only be used asintermediate compounds, but also be used for further constructing complex active compounds; at the same time, the compounds have great potential for drug activity.
