4793-90-2

Upstream product

• 1071850-00-4 potassium 2-nitro-5-methoxylbenzoate 
• 104-94-9 4-methoxy-aniline 
• 92022-96-3 N-(5-chloro-2-nitrophenyl)-N-(4-methoxyphenyl)amine 
• 124-41-4 sodium methylate 
• 491-11-2 3-chloro-4-nitrophenol 
• 28987-59-9 3-chloro-4-nitroanisole 

Relevant academic research and scientific papers

Decarboxylative ipso Amination of Activated Benzoic Acids

In the presence of a bimetallic Pd/Cu system with 1,10-phenanthroline as the ligand and either air or N-methylmorpholine N-oxide as the oxidant, electron-deficient benzoic acids undergo oxidative decarboxylative coupling with unprotected amines. This operationally simple aniline synthesis is widely applicable with respect to the amine and gives good yields, even on multigram scale. The orthogonality of this reaction to other Pd-catalyzed cross-couplings allows the concise synthesis of multisubstituted arenes by sequential C?C, C?Cl, and C?N functionalizations. Mechanistic investigations suggest the intermediacy of a hypervalent Pd species.

RECEPTOR FUNCTION REGULATING AGENT

The present invention relates to a GPR40 receptor function regulator comprising a fused imidazole compound represented by the formula: wherein each symbol is as defined in the specification, or a salt thereof or a prodrug thereof. The GPR40 receptor funct