28987-59-9

Usage

Uses

Used in Pharmaceutical Industry:
2-Chloro-4-methoxynitrobenzene is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique chemical structure allows for the development of new drugs with potential therapeutic applications.
Used in Agricultural Chemical Industry:
2-Chloro-4-methoxynitrobenzene is also utilized as an intermediate in the production of agricultural chemicals, contributing to the development of effective pest control agents and other agrochemical products.
Used in Dye and Pigment Industry:
2-Chloro-4-methoxynitrobenzene is used as a raw material in the manufacturing of dyes and pigments, enabling the creation of a wide range of colors for various applications, including textiles, plastics, and printing inks.
Safety Precautions:
It is important to handle 2-Chloro-4-methoxynitrobenzene with care, as it is toxic if ingested and can cause irritation upon contact with the skin or eyes. Additionally, it may release toxic fumes when heated to decomposition. Therefore, proper safety guidelines and regulations should be followed during its storage and handling to ensure the safety of workers and the environment.

InChI:InChI=1/C7H6ClNO3/c1-12-5-2-3-7(9(10)11)6(8)4-5/h2-4H,1H3

Upstream product

• 491-11-2 3-chloro-4-nitrophenol 
• 77-78-1 dimethyl sulfate 
• 74-88-4 methyl iodide 
• 2845-89-8 1-chloro-3-methoxy-benzene 
• 40140-91-8 3-chloro-4-nitrosophenol 
• 1882-69-5 5-methoxy-2-nitro-benzoic acid 
• 541-73-1 1,3-Dichlorobenzene 
• 611-06-3 2,4-dichloronitrobenzene 
• 124-41-4 sodium methylate 
• 2106-50-5 2-chloro-4-fluoro-1-nitrobenzene 
• 615-58-7 2,4-dibromophenol 
• 108-43-0 3-monochlorophenol 

Downstream Products

• 28093-74-5 N-cyclohexyl-5-methoxy-2-nitro-aniline 
• 107518-77-4 5-methoxy-2-nitro-N-(2-N-phthalimidoethyl)aniline 
• 90005-98-4 (5-methoxy-2-nitrophenyl)(methyl)sulfane 
• 860734-04-9 bis-(5-methoxy-2-nitro-phenyl)-sulfide 
• 69397-93-9 N-methyl-5-methoxy-2-nitroaniline 
• 854651-57-3 N,N-diethyl-N'-(5-methoxy-2-nitro-phenyl)-propanediyldiamine 
• 872807-72-2 N⁴,N⁴-diethyl-N¹-(5-methoxy-2-nitro-phenyl)-1-methyl-butanediyldiamine 
• 35350-40-4 bis-(5-methoxy-2-nitro-phenyl)-disulfide 
• 704-14-3 3-methoxy-6-nitro-phenol 
• 16133-49-6 5-methoxy-2-nitroaniline 
• 6480-66-6 2,6-dichloro-4-methoxyaniline 
• 875241-65-9 4-methoxy-1-nitro-2-phenoxybenzene 
• 29242-84-0 2-chloro-4-methoxyaniline 
• 141973-33-3 N₁-(5-methoxy-2-nitrophenyl)ethane-1,2-diamine 

Relevant academic research and scientific papers

Quinoxaline compound, preparation method and application of quinoxaline compound in medicine

The invention provides a quinoxaline compound, a preparation method and application of the quinoxaline compound in medicine, and particularly relates to a quinoxaline compound with PAR4 antagonistic activity, a preparation method of the quinoxaline compound, a pharmaceutical composition containing the quinoxaline compound and application of the quinoxaline compound. Specifically, the invention provides a compound shown as a general formula I and/or II or a tautomer or pharmaceutically acceptable salt thereof, a preparation method of the compound, and application of the compound or the tautomer or the pharmaceutically acceptable salt in medicines for preventing and/or treating thromboembolic diseases.

Benzotriazine compound with PAR4 antagonistic activity and application thereof

The invention discloses a benzotriazine compound with PAR4 antagonistic activity and application thereof. The present invention relates to a compound of formula (I) or a stereoisomer, tautomer, pharmaceutically acceptable salt, ester, solvate or prodrug t

Inexpensive NaX (X = I, Br, Cl) as a halogen donor in the practical Ag/Cu-mediated decarboxylative halogenation of aryl carboxylic acids under aerobic conditions

Versatile and practical Ag/Cu-mediated decarboxylative halogenation between readily available aryl carboxylic acids and abundant NaX (X = I, Br, Cl) has been achieved under aerobic conditions in moderate to good yields. The halodecarboxylation is shown to be an effective strategy for S-containing heteroaromatic carboxylic acid and benzoic acids with nitro, chloro and methoxyl substituents at the ortho position. A gram-scale reaction and a three-step procedure to synthesize iniparib have been performed to evaluate the practicality of this protocol. A preliminary mechanistic investigation indicates that Cu plays a vital role and a radical pathway is involved in the transformation.

BICYCLIC HETEROARYL SUBSTITUTED COMPOUNDS

Disclosed are compounds of Formula (I) to (VIII): (I) (II) (III) (IV) (V) (VI) (VII) (VIII); or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate or prodrug thereof, wherein R3 is a bicyclic heteroaryl group substituted with zero to 3 R3a; and R1, R2, R3a, R4, and n are defined herein. Also disclosed are methods of using such compounds as PAR4 inhibitors, and pharmaceutical compositions comprising such compounds. These compounds are useful in inhibiting or preventing platelet aggregation, and are useful for the treatment of a thromboembolic disorder or the primary prophylaxis of a thromboembolic disorder.

Synthetic method of aryl halide taking aryl carboxylic acid as raw material

A synthetic method of an aryl halide taking aryl carboxylic acid as a raw material is characterized in that a corresponding aryl halide is formed by carrying out substitution reaction on an aryl carboxylic acid compound and haloid salt MX in an organic solvent under the condition that oxygen, a silver catalyst, a copper additive and a bidentate nitrogen ligand exist, wherein M in MX represents alkali metal or alkaline earth metal, and X represents F, Cl, Br or I. Compared with a conventional aryl halide synthetic method, the synthetic method disclosed by the invention has the obvious advantages that reaction raw materials (comprising aryl carboxylic acid and MX) are cheap and easy to obtain, the using amount of a metal catalyst is small, pollution to the environment when the oxygen is used as an oxidant is the smallest, good tolerance to various functional groups on an aromatic ring is obtained, the yield is high, and the like. The synthetic method disclosed by the invention can be widely applied to synthesis in the fields of medicine, materials, natural products and the like in industry and academia.

Decarboxylative Halogenation and Cyanation of Electron-Deficient Aryl Carboxylic Acids via Cu Mediator as Well as Electron-Rich Ones through Pd Catalyst under Aerobic Conditions

Simple strategies for decarboxylative functionalizations of electron-deficient benzoic acids via using Cu(I) as promoter and electron-rich ones by employing Pd(II) as catalyst under aerobic conditions have been established, which lead to smooth synthesis of aryl halides (-I, Br, and Cl) through the decarboxylative functionalization of benzoic acids with readily available halogen sources CuX (X = I, Br, Cl), and easy preparation of benzonitriles from decarboxylative cyanation of aryl carboxylic acids with nontoxic and low-cost K4Fe(CN)6 under an oxygen atmosphere for the first time.

Production method of 3-ethoxy-4-nitrophenol

The invention discloses a production method of 3-ethoxy-4-nitrophenol. The low-price m-dichlorobenzene is used instead of the high-price resorcinol as the raw material, and the methoxy is converted into the hydroxy; and a simple alkaline process is used instead of the conventional hydrogen bromide/acetic acid system to prepare the 3-ethoxy-4-nitrophenol. By using low-price m-dichlorobenzene instead of the high-price resorcinol as the raw material to prepare the 3-ethoxy-4-nitrophenol, the method has the advantages of simple synthesis steps, low pollution, environment friendliness, high product quality, high yield, low production cost and normal-pressure operation, and can implement industrial production.

Silver-catalyzed decarboxylative halogenation of carboxylic acids

Decarboxylative halogenation of carboxylic acids catalyzed by silver carbonate is reported. ortho-Nitrobenzoic acids react with copper(II) chloride or bromide in DMF/DMSO at 130-140 °C leading to the corresponding aryl halides in moderate to good yields.

KINASE INHIBITORS AND METHODS OF USE

The present invention provides chemical entities or compounds and pharmaceutical compositions thereof that are capable of modulating certain protein kinases such as mTor, tyrosine kinases, and/or lipid kinases such as PI3 kinase. Also provided in the present invention are methods of using these compositions to modulate activities of one or more of these kinases, especially for therapeutic applications.

Nitration of some aromatic compounds by sodium nitrate in the presence of benzyltriphenylphosphonium peroxodisulfate

A simple, mild, and regioselective method for the nitration of some aromatic compounds using sodium nitrate in the presence of benzyltriphenylphosphonium peroxodisulfate in acetonitrile as solvent is reported. Mild reaction conditions and good to excellent yields of the products are the noteworthy advantages of the method. Copyright Taylor & Francis Group, LLC.