480-14-8

Basic information

• Product Name: 3,5-DIHYDROXY-7-METHOXYFLAVONE
• Synonyms: Izalpinine
• CAS NO: 480-14-8
• Molecular Formula: C₁₆H₁₂O₅
• Molecular Weight: 284.2635
• Product Categories: Tri-substituted Flavones
• Mol File: 480-14-8.mol
• Article Data: 2

Chemical Properties

• Melting Point: 195 °C
• Boiling Point: 512.9°Cat760mmHg
• Flash Point: 195.9°C
• Appearance: /
• Density: 1.445g/cm³
• Vapor Pressure: 2.41E-11mmHg at 25°C
• Refractive Index: 1.68
• PKA: 6.16±0.40(Predicted)
• CAS DataBase Reference: 3,5-DIHYDROXY-7-METHOXYFLAVONE(CAS DataBase Reference)
• NIST Chemistry Reference: 3,5-DIHYDROXY-7-METHOXYFLAVONE(480-14-8)
• EPA Substance Registry System: 3,5-DIHYDROXY-7-METHOXYFLAVONE(480-14-8)

Safety Data

• Hazardous Substances Data: 480-14-8(Hazardous Substances Data)

Usage

General Description

3,5-Dihydroxy-7-methoxyflavone is a naturally occurring flavonoid compound found in various plants, particularly in the leaves and stems of the Scutellaria baicalensis plant. It is known for its antioxidant and anti-inflammatory properties, making it a potential candidate for use in pharmaceuticals and dietary supplements. Studies have shown that 3,5-dihydroxy-7-methoxyflavone has the ability to inhibit the production of inflammatory mediators and reduce oxidative stress in the body, making it a promising compound for the treatment of various inflammatory and oxidative stress-related conditions. It is also being researched for its potential in cancer prevention and treatment due to its anti-tumor and anti-proliferative properties. Overall, 3,5-dihydroxy-7-methoxyflavone has shown potential for various therapeutic applications and continues to be studied for its health benefits.

InChI:InChI=1/C16H12O5/c1-20-10-7-11(17)13-12(8-10)21-16(15(19)14(13)18)9-5-3-2-4-6-9/h2-8,17,19H,1H3

Upstream product

• 1616279-97-0 3-(benzyloxy)-5,7-dihydroxy-2-phenyl-4H-chromen-4-one 
• 93-97-0 benzoic acid anhydride 
• 6665-74-3 5,7-dihydroxy-3-methoxyflavone 
• 17874-42-9 2'-hydroxy-2,4',6'-trimethoxyacetophenone 
• 548-83-4 galangin 
• 67-64-1 acetone 
• 77-78-1 dimethyl sulfate 
• 480-13-7 2,3-dihydro-3,5-dihydroxy-7-methoxyflavone 
• 26964-29-4 3,5,7-trimethoxyflavone 
• 70786-48-0 5-hydroxy-3,7-dimethoxyflavone 

Relevant articles and documents

Galangin 3-benzyl-5-methylether derivatives function as an adiponectin synthesis-promoting peroxisome proliferator-activated receptor γ partial agonist

The upregulation of adiponectin production has been suggested as a novel strategy for the treatment of metabolic diseases. Galangin, a natural flavonoid, exhibited adiponectin synthesis-promoting activity during adipogenesis in human bone marrow mesenchymal stem cells. In target identification, galangin bound both peroxisome proliferator-activated receptor (PPAR) γ and estrogen receptor (ER) β. Novel galangin derivatives were synthesized to improve adiponectin synthesis-promoting compounds by increasing the PPARγ activity of galangin and reducing its ERβ activity, because PPARγ functions can be inhibited by ERβ. Three galangin 3-benzyl-5-methylether derivatives significantly promoted adiponectin production by 2.88-, 4.47-, and 2.76-fold, respectively, compared to the effect of galangin. The most potent compound, galangin 3-benzyl-5,7-dimethylether, selectively bound to PPARγ (Ki, 1.7 μM), whereas it did not bind to ERβ. Galangin 3-benzyl-5,7-dimethylether was identified as a PPARγ partial agonist in docking and pharmacological competition studies, suggesting that it may have diverse therapeutic potential in a variety of metabolic diseases.