480-98-8Relevant articles and documents
Discovery and optimization of a novel series of dyrk1b kinase inhibitors to explore a MEK resistance hypothesis
Kettle, Jason G.,Ballard, Peter,Bardelle, Catherine,Cockerill, Mark,Colclough, Nicola,Critchlow, Susan E.,Debreczeni, Judit,Fairley, Gary,Fillery, Shaun,Graham, Mark A.,Goodwin, Louise,Guichard, Sylvie,Hudson, Kevin,Ward, Richard A.,Whittaker, David
supporting information, p. 2834 - 2844 (2015/04/14)
Potent and selective inhibitors of Dyrk1B kinase were developed to explore the hypothesis, based on siRNA studies, that Dyrk1B may be a resistance mechanism in cells undergoing a stress response.