480445-50-9Relevant academic research and scientific papers
A solid-phase approach towards the synthesis of PDE5 inhibitors.
Beer, David,Bhalay, Gurdip,Dunstan, Andrew,Glen, Angela,Haberthuer, Sandra,Moser, Heinz
, p. 1973 - 1976 (2002)
PDE5 inhibitors based upon the xanthine scaffold 8 have been expediently synthesized using a solid-phase route. Attachment of the xanthine scaffold 8 using the Rink chloride linker 4 and N-1 functionalization using Mitsunobu chemistry is described. A library of compounds was produced in multi-milligram quantities with excellent purities and acceptable yields. The compounds were tested for their PDE5 inhibitory activity.
