480445-51-0

Basic information

• Product Name: 8-(4-bromo-benzyl)-3-isobutyl-3,7-dihydro-purine-2,6-dione
• Synonyms: 8-(4-bromo-benzyl)-3-isobutyl-3,7-dihydro-purine-2,6-dione
• CAS NO: 480445-51-0
• Molecular Weight: 377.241
• Mol File: 480445-51-0.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 8-(4-bromo-benzyl)-3-isobutyl-3,7-dihydro-purine-2,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 8-(4-bromo-benzyl)-3-isobutyl-3,7-dihydro-purine-2,6-dione(480445-51-0)
• EPA Substance Registry System: 8-(4-bromo-benzyl)-3-isobutyl-3,7-dihydro-purine-2,6-dione(480445-51-0)

Safety Data

• Hazardous Substances Data: 480445-51-0(Hazardous Substances Data)

Upstream product

• 54052-65-2 1-isobutyl-5-nitroso-6-amino uracil 
• 54052-62-9 5,6-diamino-1-(2-methylpropyl)-2,4-(1H,3H)-pyrimidine dione 
• 56075-75-3 6-amino-1-isobutyl-1,3-dihydropyrimidine-2,4-dione 
• 480445-50-9 N-(6-amino-1-isobutyl-2,4-dioxo-1,2,3,4-tetrahydro-pyrimidin-5-yl)-2-(4-bromo-phenyl)-acetamide 

Relevant articles and documents

A solid-phase approach towards the synthesis of PDE5 inhibitors.

PDE5 inhibitors based upon the xanthine scaffold 8 have been expediently synthesized using a solid-phase route. Attachment of the xanthine scaffold 8 using the Rink chloride linker 4 and N-1 functionalization using Mitsunobu chemistry is described. A library of compounds was produced in multi-milligram quantities with excellent purities and acceptable yields. The compounds were tested for their PDE5 inhibitory activity.