56075-75-3Relevant articles and documents
Approach to the library of fused pyridine-4-carboxylic acids by combes-type reaction of acyl pyruvates and electron-rich amino heterocycles
Volochnyuk, Dmitriy M.,Ryabukhin, Sergey V.,Plaskon, Andrey S.,Dmytriv, Yuri V.,Grygorenko, Oleksandr O.,Mykhailiuk, Pavel K.,Krotko, Dmitriy G.,Pushechnikov, Alexei,Tolmachev, Andrey A.
scheme or table, p. 510 - 517 (2010/09/05)
A library of fused pyridine-4-carboxylic acids (including pyrazolo[3,4-b]pyridines, isoxazolo[5,4-b]pyridines, furo[2,3-b]pyridines, thieno[2,3-b]pyridines, and pyrido[2,3-d]pyrimidines) was generated by Combes-type reaction of acyl pyruvates and electron-rich amino heterocycles followed by hydrolysis of the ester. The library members were also demonstrated to undergo the standard combinatorial transformations including amide coupling and esterification, as well as less common heterocyclizations to 1,2,4-triazoles and 1,2,4-oxadiazoles.
XANTHINE DERIVATIVES AS A2B ADENOSINE RECEPTOR ANTAGONISTS
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Page 75, (2010/02/09)
Disclosed are compounds that are A2B adenosine receptor antagonists, useful for treating various disease states, including asthma and diarrhea.
1,3-Dialkyl-8-(p-sulfophenyl)xanthines: Potent Water-Soluble Antagonistst for A1- and A2-Adenosine Receptors
Daly, J.W.,Padgett, W.,Shamim, M.T.,Butts-Lamb, P.,Waters, J.
, p. 487 - 492 (2007/10/02)
A series of 8-(substituted phenyl) derivatives of Theophylline and other 1,3-dialkylxanthines were evaluated for potency and selectivity as antagonists at A1- and A2-adenosine receptors in brain tissue.Theophylline has a similar pote
