48067-72-7Relevant academic research and scientific papers
Hetero-Diels–Alder Cycloaddition with RAFT Polymers as Bioconjugation Platform
Barner-Kowollik, Christopher,Bauer, Dennis M.,Beloqui, Ana,Delaittre, Guillaume,Fruk, Ljiljana,Glassner, Mathias,Langer, Marcel,Mane, Shivshankar R.
, p. 19951 - 19955 (2020)
We introduce the bioconjugation of polymers synthesized by RAFT polymerization, bearing no specific functional end group, by means of hetero-Diels–Alder cycloaddition through their inherent terminal thiocarbonylthio moiety with a diene-modified model protein. Quantitative conjugation occurs over the course of a few hours, at ambient temperature and neutral pH, and in the absence of any catalyst. Our technology platform affords thermoresponsive bioconjugates, whose aggregation is solely controlled by the polymer chains.
Thermal and conductivity properties of poly(ethylene glycol)-based cyclopolymers
Blazquez, Enrique,Mustarelli, Piercarlo,Pasini, Dario,Righetti, Pier Paolo,Tomasi, Corrado
, p. 2524 - 2529 (2004)
Cyclopolymers bearing a hexaethylene glycol-based malonate crown ether, have been synthesized and characterized from the point of view of their thermal properties and of their use, in thin films, either on their own or as blends with poly(ethylene glycol), in lithium ion battery applications.
Redox-sensitive disassembly of amphiphilic copolymer based micelles
Ryu, Ja-Hyoung,Roy, Raghunath,Ventura, Judy,Thayumanavan
, p. 7086 - 7092 (2010)
Amphiphilic polymers of different hydrophilic-lipophilic ratios were prepared by free radical polymerization using two monomers consisting of triethylene glycol as the hydrophilic part and an alkyl chain connected by disulfide bond as the hydrophobic part. These polymers form micelle-like nanoassemblies in aqueous media and can encapsulate hydrophobic drug molecules up to 14% of their mass. In a reducing environment, these polymeric micelles disassemble and dissolve in water, since the amphiphilic polymers are converted into hydrophilic polymers upon cleavage of the disulfide bond. This disassembly event results in the release of hydrophobic molecules that had been encapsulated inside the micelle, the rate of which was found to be dependent on the concentration of the reducing agent, glutathione (GSH). In vitro experiments also show that the GSH-dependent release of the doxorubicin can be used to effect cytotoxicity in MCF-7 cells.
Construction of an Artificial Glutathione Peroxidase Active Site on Copolymer Vesicles
Yin, Yanzhen,Huang, Xin,Lv, Chunyan,Wang, Liang,Yu, Shuangjiang,Luo, Quan,Xu, Jiayun,Liu, Junqiu
experimental part, p. 1505 - 1516 (2011/10/09)
To construct an efficient GPx mimic, a novel method for preparing polymer-based vesicles carrying GPx-active sites was developed. A series of block copolymers loaded with recognition and catalytic sites were synthesized based on polystyrene-block-poly[tri(ethylene glycol) methyl ether acrylate]s (PS-PMEO3MAs). By altering the molar ratio of the functional copolymers, vesicles with GPx activity were obtained by self-assembly of these functional copolymers through blending. The optimum GPx mimic constructed by the blending process exhibited high catalytic activity and acted as a real catalyst with typical saturation kinetics behavior. The method may be of benefit for designing other enzyme mimics and may cast a light on constructing other biologically related functional nanoparticles.Self-assembly of functional copolymers through blending is a novel and simple method to construct efficient glutathione peroxidase(GPx) mimics. The optimum blended GPx mimic is obtained by optimizing the structure of the functional block copolymers and altering the ratio of the functional block copolymers. The blended GPx mimic exhibits remarkable catalytic activity and acts as a real catalyst with typical saturation kinetics behavior.
Synthesis and hydrolysis behavior of side-chain functionalized norbornenes
Carlise, Joseph R.,Kriegel, Robert M.,Rees Jr., William S.,Weck, Marcus
, p. 5550 - 5560 (2007/10/03)
The stabilities of various functionalized norbornenes that are monomers for the ring-opening metathesis polymerization (ROMP) in aqueous solution were evaluated toward hydrolysis under a range of temperatures (37, 60, and 80 °C) and pH values (3-9). All monomers contain hydrolyzable linkages to pendant functional groups, and conclusions were drawn relating to how the chemical diversity of these pendant functional groups, in accordance with the pH and temperature variations, affect hydrolysis of the aforementioned linkages. The hydrolysis was monitored by reverse phase HPLC analysis, and/or NMR spectroscopy. As expected, monomers containing ester linkages were fairly labile at higher pH values, while acetal-based linkers were cleaved at lower pH values. β-Amino ester groups experienced a significant increase in hydrolysis rate, while carboxylic acid-containing monomers did not follow any clear trend. Saccharide-containing monomers exhibited unique behaviors for various pH values and temperature ranges.
Synthesis and characterization of network type single ion conductors
Sun, Xiao-Guang,Reeder, Craig L.,Kerr, John B.
, p. 2219 - 2227 (2007/10/03)
New single ion conductors were synthesized by grafting the allyl group-containing lithium salt, lithium bis(allylmalonato)borate (LiBAMB), onto allyl group-containing comb-branch polyacrylate or polymethacrylate ethers by means of hydrosilylation. The highest ambient temperature conductivity of 3.5 × 10-7 S cm-1 was obtained for a polyacrylate ether-based single ion conductor containing eight EO units in the side chain and five EO units in the cross-linking side chain, to which the anion was fixed with a salt concentration of EO/Li = 20. For polyacrylate ether-based single ion conductors, an increase of chain length in both side chains and cross-linking anion chains favors an increase of ionic conductivity. The addition of 50 wt % EC/DMC (1/1, wt/wt) increased the ionic conductivity by more than 2 orders of magnitude due to both the increase in ionic mobility from the liquid phase and the increase in the concentration of free ions from the high dielectric constant of the solvent. The preliminary Li/Li cycling profiles of dry polyacrylate- and polymethacrylate ether-based single ion conductors are encouraging as almost no concentration polarization or relaxation was observed. The observed increase in cell potential with cycling is apparently due to an increase in the interfacial impedance associated with the SEI layer, and the cell failure is accompanied by the decomposition of the ester bond of the polyacrylate backbone.
