4810-79-1

Usage

Uses

Used in Food and Beverage Industry:
4-Isobutyl-pyridine is used as a flavoring ingredient for its aromatic qualities, enhancing the taste profiles of various food and drink products.
Used in Perfumes and Personal Care Products:
In the fragrance industry, 4-isobutyl-pyridine serves as a fragrance ingredient, contributing to the creation of complex and appealing scents for perfumes and personal care items.
Used in Antimicrobial Applications:
4-Isobutyl-pyridine has been studied for its potential antimicrobial properties, indicating that it could be utilized in applications where control of microbial growth is necessary.
Used in Insecticidal Applications:
4-ISOBUTYL-PYRIDINE has also demonstrated insecticidal activity, suggesting that it could be employed in products designed to control or repel insects.
It is crucial to handle 4-isobutyl-pyridine with care due to its potential harmful effects if ingested or inhaled, and its ability to cause skin and eye irritation.

InChI:InChI=1/C9H13N/c1-8(2)7-9-3-5-10-6-4-9/h3-6,8H,7H2,1-2H3

Upstream product

• 110-86-1 pyridine 
• 97-72-3 2-Methylpropionic anhydride 
• 108-89-4 picoline 
• 187737-37-7 propene 
• 75-29-6 isopropyl chloride 
• 75-26-3 isopropyl bromide 
• 6760-50-5 2-methyl-1-(4-pyridyl)-1-propene 
• 135351-36-9 2-(2,2-Diethoxy-ethyl)-4-methyl-pentanenitrile 
• 542-54-1 isocapronitrile 
• 80891-12-9 diisopropyl-1-ethoxycarbonyl-1,4-dihydropyridine-4-phosphonate 
• 882525-03-3 4-(diisopropoxy-phosphoryl)-4-(1-hydroxy-2-methyl-propyl)-4H-pyridine-1-carboxylic acid ethyl ester 
• 135351-44-9 2-[2-(2,2-Diethoxy-ethyl)-4-methyl-pentyl]-[1,3]dioxolane 
• 135351-40-5 2-(2,2-Diethoxy-ethyl)-2-[1,3]dioxolan-2-ylmethyl-4-methyl-pentanenitrile 

Downstream Products

• 138761-51-0 4-(1-fluoro-2-methylpropyl)pyridine 

Relevant academic research and scientific papers

Efficient Diastereoselective Three-Component Synthesis of Pipecolic Amides

An efficient Ugi-type three-component reaction (U-3CR) for the synthesis of pipecolic amides is reported. The U-3CR between electronically diverse isocyanides, carboxylic acids and 4-substituted Δ1-piperideines proceeds in a highly diastereoselective fashion. The Δ1-piperideines are obtained by NCS-mediated oxidation of the corresponding 4-substituted piperidines, which in turn are generated by an efficient two-step procedure involving the alkylation of 4-picoline and subsequent catalytic hydrogenation of the pyridine ring. We demonstrate the utility of this U-3CR, in combination with the convertible isocyanide 2-bromo-6-isocyanopyridine, in the synthesis of the anticoagulant argatroban.

Photocatalyzed Site-Selective C(sp3)-H Functionalization of Alkylpyridines at Non-Benzylic Positions

Tetrabutylammonium decatungstate (TBADT)-photocatalyzed C-H functionalization of alkylpyridines was investigated. Unlike alkylbenzene counterparts, alkylation of α-C-H bonds did not proceed for the reaction of 2- and 4-alkylpyridines and reluctantly proceeded for 3-alkylpyridines, which allow site-selective C(sp3)-H functionalization at nonbenzylic positions. The observed nonbenzylic site selectivities are rationalized by the polar inductive effects of pyridyl groups in the SH2 transition states. Consecutive γ-functionalization and α-bromofunctionalization were successfully carried out in selected cases.

Regioselective synthesis of 4-alkylpyridines from pyridine and aldehydes via dipole reversal process of 1,4-dihydropyridine phosphonate

4-Alkylation of pyridine has been accomplished by the reaction of ylides, derivated from 1,4-dihydropyridine phosphonate via phosphonioalkoxycarbonylation of pyridine with aldehydes and subsequent elimination of diisopropyl phosphate followed by aromatization with potassium tert-butoxide.

Bis(trimethylsilyl)ketene acetals as C,O-dinucleophiles: One-pot formation of polycyclic γ- and δ-lactones from pyridines and pyrazines

Bis(trimethylsilyl)ketene acetals react with pyridines, quinoline and isoquinoline in the presence of stoichiometric amounts of methyl chloroformate to give the corresponding dihydropyridine-, dihydroquinoline- and dihydroisoquinoline-substituted carboxylic acids in satisfactory yields. The regio- and diastereoselectivities of the addition reactions, together with the presence or absence of rotamers, have been established. The isolated acids react with peracids to give β-hydroxy-δ-lactones through an intramolecular reaction. Similar lactonizations could also be brought about directly from the azaaromatic compounds in one-pot reactions with silica gel, iodine or bromine. In these cases δ-lactones or β-halo-δ-lactones were produced. The behaviour of pyrazines in these transformations is peculiar, since methyl chloroformate on its own induces the formation, through interaction with both nitrogen atoms, of polycyclic γ-lactones, a reaction formally reminiscent of the double nucleophilic addition of the same ketene acetals to (arene)tricarbonylchromium complexes. Most of the new structures were assigned through X-ray crystal structure determinations. Wiley-VCH Verlag GmbH & Co. KGaA, 2005.

LINCOMYCIN DERIVATIVES POSSESSING ANTIBACTERIAL ACTIVITY

Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

Lincomycin derivatives possessing antibacterial activity

Novel lincomycin derivatives are disclosed. These lincomycin derivatives exhibit antibacterial activity. As the compounds of the subject invention exhibit potent activities against bacteria, including gram positive organisms, they are useful antimicrobial agents. Methods of synthesis and of use of the compounds are also disclosed.

AN IMPROVED SYNTHESIS OF 4-SUBSTITUTED PYRIDINES FROM NITRILES

4-substituted pyridines have been prepared by a four-step sequence in 23-27percent overall yield from nitriles.