4812-99-1

Basic information

• Product Name: 4-hydroxy-1,6-diphenyl-pyridin-2(1H)-one
• Synonyms: 4-hydroxy-1,6-diphenyl-pyridin-2(1H)-one
• CAS NO: 4812-99-1
• Molecular Weight: 263.296
• Mol File: 4812-99-1.mol

Chemical Properties

• CAS DataBase Reference: 4-hydroxy-1,6-diphenyl-pyridin-2(1H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 4-hydroxy-1,6-diphenyl-pyridin-2(1H)-one(4812-99-1)
• EPA Substance Registry System: 4-hydroxy-1,6-diphenyl-pyridin-2(1H)-one(4812-99-1)

Safety Data

• Hazardous Substances Data: 4812-99-1(Hazardous Substances Data)

Upstream product

• 261505-51-5 4-hydroxy-6,7-diphenyl-pyrano[3,2-c]pyridine-2,5(6H)-dione 
• 98-86-2 acetophenone 
• 62-53-3 aniline 
• 58169-03-2 2-phenyl-2-(phenylamino)propanenitrile 
• 1749-19-5 phenyl(1-phenylethylidene)amine 
• 173208-53-2 3-acetyl-4-hydroxy-1,6-diphenyl-pyridin-2(1H)-one 

Downstream Products

• 380631-60-7 4-hydroxy-3-iodo-1,6-diphenylpyridin-2(1H)-one 
• 685891-24-1 4-chloro-3-nitro-1,6-diphenylpyridin-2(1H)-one 
• 261505-72-0 4-hydroxy-3-nitro-1,6-diphenyl-pyridin-2(1H)-one 

Relevant articles and documents

Synthesis of Acetyl and Iodo Derivatives of 4-Hydroxy-6-phenyl-6H-pyrano[3,2-c]pyridine-2,5-diones and 4-Hydroxy-1-phenylpyridin-2(1H)-ones

A simple and efficient method has been described for the synthesis of acetyl and iodo derivatives of 4-hydroxy-6-phenyl-6H-pyrano[3,2-c]pyridine-2,5-diones 1 and 4-hydroxy-1-phenylpyridin-2(1H)-ones 5. Compounds 1 with phenyl and alkyl substituent at C(7) and C(8), respectively, can be easily acetylated by refluxing in a mixture of acetic acid and polyphosphoric acid to give 3-acetyl-4-hydroxy-6-phenyl-6H-pyrano[3,2-c]pyridine-2,5-diones 2 in excellent yields. Compounds 1 and 5 can be iodinated with iodine and anhydrous sodium carbonate in boiling dioxane to give 4-hydroxy-3-iodo-6-phenyl-6H-pyrano[3,2-c]pyridine-2,5-diones 3 and 4-hydroxy-3-iodo-1-phenylpyridin-2(1H)-ones 6, respectively, in good yields. The structures were confirmed using infrared, nuclear magnetic resonance, and elemental analysis.

Thermal Cyclization of 3-Acyl-4-azidopyridines to Isoxazolo[4,3-c]pyridines

4-Azidopyridines such as 3-acetyl-4-azido-2-pyridones 3 or 4-azido-3-ethoxycarbonylpyridine 7 with reactive ortho-acyl substituents were obtained from the 4-hydroxy-2-pyridones 1, resp. 5 via 4-tosyloxy-2-pyridones 2 or the 2,4-dichloropyridine 6. DSC-ass

Thermal cyclization of 4-azido-3-nitropyridines to furoxanes [1]

4-Chloro-3-nitro-2-pyridines 3 and 10, obtained from 4-hydroxy-2-pyridones 1 and 8 after nitration and chlorination, gave with sodium azide 4-azido-3-nitropyridines 4 and 11, which cyclized on thermolysis to furoxans 6 and 12. Desoxygenation of the furoxa