58169-03-2

Upstream product

• 60-29-7 diethyl ether 
• 20102-12-9 2-hydroxy-2-phenylpropionitrile 
• 62-53-3 aniline 
• 773837-37-9 sodium cyanide 
• 98-86-2 acetophenone 
• 1749-19-5 phenyl(1-phenylethylidene)amine 
• 7677-24-9 trimethylsilyl cyanide 
• 536-74-3 phenylacetylene 
• 630-18-2 tert-butyl isocyanide 
• 4316-35-2 acetophenone dimethyl acetal 
• 631-57-2 Acetyl cyanide 
• 143-33-9 sodium cyanide 
• 151-50-8 potassium cyanide 
• 142-04-1 aniline hydrochloride 

Downstream Products

• 68168-56-9 2-anilino-2-phenyl-propionic acid amide 
• 613-91-2 acetophenone oxime 
• 779-54-4 (S)-N-phenyl-1-phenylethylamine 
• 380634-32-2 3-acetyl-4-hydroxy-5-methyl-1,6-diphenylpyridin-2(1H)-one 
• 685888-92-0 3-Acetyl-5-ethyl-4-hydroxy-1,6-diphenylpyridin-2(1H)-one 
• 380634-47-9 3-acetyl-4-hydroxy-6-isopropyl-1-phenylpyridin-2(1H)-one 
• 503426-27-5 6-tert-butyl-3-acetyl-4-hydroxy-1-phenylpyridin-2(1H)-one 
• 261505-70-8 3-acetyl-4-hydroxy-1,6-diphenylpyridin-2(1H)-one 
• 380631-06-1 5-ethyl-4-hydroxy-3-[N-hydroxyethanimidoyl]-1,6-diphenylpyridin-2(1H)-one 
• 503428-80-6 4-hydroxy-3-(1-methoxyiminoethyl)-1,6-diphenylpyridin-2(1H)-one 
• 380631-61-8 3-[1-ethoxyiminoethyl]-4-hydroxy-1,6-diphenylpyridin-2(1H)-one 
• 380631-66-3 3-[1-benzyloxyiminoethyl]-4-hydroxy-1,6-diphenylpyridin-2(1H)-one 
• 380634-51-5 3-[1-allyloxyiminoethyl]-4-hydroxy-1,6-diphenylpyridin-2(1H)-one 
• 380631-68-5 3-[1-ethoxyiminoethyl]-4-hydroxy-5-methyl-1,6-diphenylpyridin-2(1H)-one 

Relevant academic research and scientific papers

Design, synthesis, characterization and catalytic performance of a new cellulose-based magnetic nanocomposite in the one-pot three-component synthesis of α-aminonitriles

A sulfonated magnetic cellulose-based nanocomposite was prepared and characterized using scanning electron microscopy, energy-dispersive X-ray spectroscopy, X-ray diffraction and Fourier transform infrared spectroscopy. Then, it was used as a green nanoca

Cuboctahedral [In36(μ-OH)24(NO3)8(Imtb)24]MOF with Atypical Pyramidal Nitrate Ion in SBU: Lewis Acid-Base Assisted Catalysis and Nanomolar Sensing of Picric Acid

A robust and multifunctional cuboctahedral [In36(μ-OH)24(NO3)8(Imtb)24] MOF (In(Imtb)-MOF) with an atypical pyramidal nitrate ion-containing hitherto unknown SBU core [In9(μ-OH)6(NO3)] is reported. The intra- and interlayer nitrate ions adopt pyramidal an

Cu/Ni-doped sulfated zirconium oxide immobilized on CdFe2O4 NPs: a cheap, sustainable and magnetically recyclable inorgano-catalyst for the efficient preparation of α-aminonitriles in aqueous media

Abstract: A new multifunctional bimetallic nanocatalyst was prepared by immobilization of Cu/Ni-doped sulfated zirconium oxide on magnetic cadmium ferrite (CdFe2O4@SiO2@ZrO2/SO42?/Cu/Ni) and used as an efficient recyclable catalyst for one-pot as well as stepwise preparation of α-aminonitriles under mild conditions. The magnetic nanocatalyst was characterized by FTIR, TGA, VSM, XRD, EDX, FE-SEM, and TEM analyses. Also, the surface acidity of the catalyst was measured by pyridine adsorption assay. The catalyst possesses various active sites which could catalyst a variety of aromatic and aliphatic aldehydes to the corresponding α-amionitriles under moderate to high yields in the presence of aniline. Furthermore, transformation of ketones to the desired α-amionitriles and some bis-aminonitriles was also performed by this method. The catalyst could be readily recovered from the reaction mixture and reused for several times without significant loss of activity. Graphic abstract: A general and efficient method has been developed for transformation of a variety of aliphatic, aromatic aldehydes and ketones to the corresponding α-aminonitriles using a multifunctional recyclable CdFe2O4@SiO2@ZrO2/SO42?/Cu/Ni nanocatalyst.[Figure not available: see fulltext.]

A Discrete Tetrahedral Indium Cage as an Efficient Heterogeneous Catalyst for the Fixation of CO2 and the Strecker Reaction of Ketones

A discrete tetrahedral indium cage, {[In12(μ3-OH)4(HCO2)24(tcma)4]} (In12-GL), was synthesized solvothermally by the reaction of indium nitrate with the tripodal tricarboxylic ac

A microporous metal-organic framework catalyst for solvent-free strecker reaction and CO2 fixation at ambient conditions

The self-assembly of zinc(II) acetate tetrahydrate, a flexible tetrapyridyl ligand, tetrakis(3-pyridyloxymethylene)methane (3-tpom), a bent dicarboxylic acid, and 4,4′-(dimethylsilanediyl)bis- benzoic acid (H2L) under solvothermal conditions ha

Synthesis of α-Aminonitriles and 5-Substituted 1H-Tetrazoles Using an Efficient Nanocatalyst of Fe3O4@SiO2–APTES-supported Trifluoroacetic Acid

Fe3O4@SiO2–APTES-supported trifluoroacetic acid nanocatalyst was used for the one-pot synthesis of α-aminonitriles via a three-component reaction of aldehydes (or ketones), amines, and sodium cyanide. This method produced a high yield of 75–96% using only a small amount of the catalyst (0.05?g) in EtOH at room temperature. The catalyst was also employed for the synthesis of 5-substituted 1H-tetrazoles from nitriles and sodium azide in EtOH at 80°C. The tetrazoles were produced with good-to-excellent yields in a short reaction time of 4?h. Both synthetic methods were carried out in the absence of an organic volatile solvent. Because the supported trifluoroacetic acid generated a solid acid on the surface, thus the acid corrosiveness was not a serious challenge. This heterogeneous nanocatalyst was magnetically recovered and reused several times without significant loss of catalytic activity.

Gallic acid-functionalized magnetic nanoparticles: a convenient and green approach for synthesis of α-aminonitriles under solvent-free conditions

Abstract: Gallic acid-coated magnetic nanoparticles were efficiently prepared, characterized by Fourier transform infrared spectroscopy, X-ray diffraction, vibrating sample magnetometry, scanning electron microscopy, and transmission electron microscopy, and employed as an environmentally friendly and recyclable catalyst for one-pot synthesis of three-component reaction via Strecker reaction, incorporating aldehydes/ketones, amines, and trimethylsilyl cyanides under solvent-free conditions. Operational simplicity, product purity, natural resources and reusability of the catalyst are considered as evident features of this protocol which will hopefully develop into an inexpensive, efficient, and clean strategy for the synthesis of α-aminonitriles. Graphical abstract: [Figure not available: see fulltext.].

Efficient synthesis of α-aminonitriles over homopiperazine sulfamic acid functionalized mesoporous silica nanoparticles (MSNs-HPZ-SO3H), as a reusable acid catalyst

Abstract: Good to excellent yields of α-aminonitriles are achieved through three-component Strecker reaction of aldehydes or ketones with amines and trimethylsilyl cyanides over homopiperazine sulfamic acid functionalized mesoporous silica nanoparticles (MSNs-HPZ-SO3H). The advantages of this protocol include: simplicity, short reaction time, high yields, ease of product isolation and reusability of the catalyst. Graphical abstract: MSNs-HPZ-SO3H is prepared as an acid catalyst and successfully used for three-component Strecker reaction of aldehydes or ketones with amines and trimethylsilyl cyanides (TMSCN) under solvent-free conditions, a straightforward strategy for the synthesis of α-aminonitriles.[Figure not available: see fulltext.].

Divergent Multistep Continuous Synthetic Transformations of Allylic Alcohol Enabled by Catalysts Immobilized in Ionic Liquid Phases.

Two individual catalytic platforms (metal- and organo-catalyzed) based on the use of an ionic liquid phase were successfully integrated for the synthesis of α-cyano-amine and cyanohydrin trimethylsilyl ethers from allylic alcohol. The right combination of continuous flow processes enabled access to the divergent preparation of two alternative and interesting intermediate compounds from the same starting material.

Design and Construction of a Chiral Cd(II)-MOF from Achiral Precursors: Synthesis, Crystal Structure and Catalytic Activity toward C-C and C-N Bond Forming Reactions

Using achiral components, a V-shaped dicarboxylic acid (H2L) and a conformationally flexible bidentate linker (bpp), a thermally stable chiral metal organic framework {[Cd(bpp)(L)(H2O)]·DMF}n (1), where H2L = 4,