4813-07-4

Upstream product

• 54-85-3 isoniazid 
• 555-16-8 4-nitrobenzaldehdye 
• 1262213-16-0 N'-[(Z)-(4-nitrophenyl)methylidene]pyridine-4-carbohydrazide 

Downstream Products

• 1262213-16-0 N'-[(Z)-(4-nitrophenyl)methylidene]pyridine-4-carbohydrazide 

Relevant academic research and scientific papers

p-Nitrobenzaldehyde isonicotinoylhydrazone

Molecules of the hydrazone C13H10N4O3 are planar and exist in the keto tautomeric form. The configuration at the azomethine C double bond N double bond is E. The structure is stabilized by a network of hydrogen

Xanthine oxidase inhibitory activity of nicotino/isonicotinohydrazides: A systematic approach from in vitro, in silico to in vivo studies

Change in life style and eating habits has led to an increased prevalence of hyperuricemia worldwide. The role of hyperuricemia is no more restricted to gout, but it has a central role in progression of CVD, hypertension, metabolic syndrome, and arthritis

Acylhydrazones as Widely Tunable Photoswitches

Molecular photoswitches have attracted much attention in biological and materials contexts. Despite the fact that existing classes of these highly interesting functional molecules have been heavily investigated and optimized, distinct obstacles and inherent limitations remain. Considerable synthetic efforts and complex structure-property relationships render the development and exploitation of new photoswitch families difficult. Here, we focus our attention on acylhydrazones: a novel, yet underexploited class of photochromic molecules based on the imine structural motif. We optimized the synthesis of these potent photoswitches and prepared a library of over 40 compounds, bearing different substituents in all four crucial positions of the backbone fragment, and conducted a systematic study of their photochromic properties as a function of structural variation. This modular family of organic photoswitches offers a unique combination of properties and the compounds are easily prepared on large scales within hours, through an atom-economic synthesis, from commercially available starting materials. During our thorough spectroscopic investigations, we identified photoswitches covering a wide range of thermal half-lives of their (Z)-isomers, from short-lived T-type to thermally stable P-type derivatives. By proper substitution, excellent band separation between the absorbance maxima of (E)- and (Z)-isomers in the UV or visible region could be achieved. Our library furthermore includes notable examples of rare negative photochromic systems, and we show that acylhydrazones are highly fatigue resistant and exhibit good quantum yields.

MFA zeotype catalyst: A greener approach for the synthesis of INH azomethine scaffolds

Herein, we are reporting the green and efficient synthesis of some pharmacologically important azomethine derivatives of isoniazide (INH) using Modified Fly Ash (MFA) as an excellent zeotic solid acid catalyst. The catalyst, by virtue of its terminal hydr

Synthesis and anti-mycobacterial activity of (E)-N′-(monosubstituted-benzylidene)isonicotinohydrazide derivatives

A series of 22 (E)-N′-(monosubstituted-benzylidene)isonicotinohydrazide derivatives have been synthesized and evaluated for their in vitro antibacterial activity against Mycobacterium tuberculosis H37Rv using Alamar Blue susceptibility test and

Four nitrobenzaldehyde isonicotinoyl-hydrazones at 120 K: Four different supramolecular structures in two and three dimensions

The molecules of 2-nitrobenzaldehyde isonicotinoylhydra-zone, C 13H10N4O3, (I), are linked into a three-dimensional framework by a combination of one N-H...N and three C-H...O hydrogen bonds. In the isomeric com