48141-64-6

Basic information

• Product Name: [R-(R*,S*)]-alpha-[1-(ethylmethylamino)ethyl]benzyl alcohol
• Synonyms: [R-(R*,S*)]-alpha-[1-(ethylmethylamino)ethyl]benzyl alcohol;(1R,2S)-1-Phenyl-2-(ethylmethylamino)-1-propanol;(αR)-α-[(S)-1-(Ethylmethylamino)ethyl]benzenemethanol;Einecs 256-359-0
• CAS NO: 48141-64-6
• Molecular Formula: C₁₂H₁₉NO
• Molecular Weight: 193.28536
• EINECS: 256-359-0
• Mol File: 48141-64-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 294.8°Cat760mmHg
• Flash Point: 104.5°C
• Appearance: /
• Density: 0.995g/cm³
• CAS DataBase Reference: [R-(R*,S*)]-alpha-[1-(ethylmethylamino)ethyl]benzyl alcohol(CAS DataBase Reference)
• NIST Chemistry Reference: [R-(R*,S*)]-alpha-[1-(ethylmethylamino)ethyl]benzyl alcohol(48141-64-6)
• EPA Substance Registry System: [R-(R*,S*)]-alpha-[1-(ethylmethylamino)ethyl]benzyl alcohol(48141-64-6)

Safety Data

• Hazardous Substances Data: 48141-64-6(Hazardous Substances Data)

Usage

General Description

"[R-(R*,S*)]-alpha-[1-(ethylmethylamino)ethyl]benzyl alcohol" is a chemical compound with a complex structure and a long name. It is a chiral molecule, meaning it has non-superimposable mirror images, and is often used in pharmaceutical and chemical research. [R-(R*,S*)]-alpha-[1-(ethylmethylamino)ethyl]benzyl alcohol has a benzyl alcohol group attached to a chiral carbon, as well as an ethylmethylaminoethyl group. It is commonly used as a precursor in the synthesis of other organic compounds, and its chiral nature makes it useful for asymmetric synthesis. Due to its complex structure, this compound requires careful handling and expertise in organic chemistry for proper synthesis and utilization.

Upstream product

• 64-67-5 diethyl sulfate 
• 299-42-3 ephedrine 
• 258827-42-8 (4S,5R)-2,3,4-Trimethyl-5-phenyl-oxazolidine 
• 579-07-7 1-Phenylpropane-1,2-dione 
• 50-00-0 formaldehyd 
• 37025-57-3 N-ethylnorephedrine 
• 74-96-4 ethyl bromide 
• 2272-83-5 (1R,2S)-N-<(2-Hydroxy-2-phenyl)-1-methyl-ethyl>-N-methylacetamid 
• 75-05-8 acetonitrile 

Downstream Products

• 139528-43-1 (1R,2S)-α-<1-(ethylmethylamino)ethyl>benzylamine 
• 139528-44-2 2-[(1R,2S)-2-(Ethyl-methyl-amino)-1-phenyl-propyl]-isoindole-1,3-dione 
• 145388-32-5 (2S)-1<2-(2-Dimethylaminoethyl)phenyl>-N-ethyl-N-methyl-2-propanamin 
• 139528-45-3 (1R,2S)-α-<1-(ethylmethylamino)ethyl>-N-cyclohexylbenzylamine 
• 145388-31-4 (2S)-2<2(Ethyl-methyl-amino)propyl>-N,N-dimethylphenylacetamid 

Relevant articles and documents

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The Reductive Cleavage of Cyclic Aminol Ethers to N,N-Dialkylamino-derivatives: Modifications to the Eschweiler-Clarke Procedure

The reductive cleavage of cyclic aminol ethers to give N-alkylamino-derivatives in very high yields can be achieved using chlorotrimethylsilane in the presence of sodium cyanoborohydride: in the case of cyclic aminol ethers derived from formaldehyde the Eschweiler-Clarke reaction can be carried out in formic acid heated under reflux in the absence of formaldehyde.

Reactions of (-)-Ephedrine, (+)-Norpseudoephedrine and Derivatives with N,N-Dimethylacetamid-dimethylacetal and N,N-Dimethylformamid-dimethylacetal

The reactivity of (-)-ephedrine (2) and (+)-norpseudoephedrine (3) towards the amid-acetals 1 a/b has been studied.Both 2 and 3 were acetylated resp. formylated at first at the amino group.Nevertheless, derivatives of 2 and 3 possessing a trisubstituted amino group react with 1 a in a sigmatropic rearrangement to ortho substituted dimethylcarbamoylmethyl derivatives.By subsequent reduction with lithiumaluminiumhydride the aromatic compounds 8, 13, and 18 with two aminoethyl groups are easily available.In contrast to these results 1 b did not furnish any rearrangement products. Keywords. (-)-Ephedrine; (+)-Norpseudoephedrine; N,N-Dimethylacetamid-dimethylacetal; N,N-Dimethylformamid-dimethylacetal; Sympathomimetic effects; Sigmatropic rearrangements.