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4815-35-4

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4815-35-4 Usage

Description

2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC ACID AMIDE, also known as 2-Aminothiophene-3-carboxamide derivative, is a white solid compound with significant pharmaceutical applications. It is recognized for its inhibitory effects on Janus kinases, which are key enzymes involved in cell signaling pathways. This property makes it a promising candidate for the treatment of various diseases, particularly myeloproliferative disorders and cancers.

Uses

Used in Pharmaceutical Industry:
2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC ACID AMIDE is used as an inhibitor of Janus kinases for the treatment of myeloproliferative disorders and cancers. Its ability to inhibit these enzymes helps in controlling cell signaling pathways that contribute to the development and progression of these diseases.
Used in Cancer Treatment:
2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC ACID AMIDE is employed as an anticancer agent, targeting the inhibition of Janus kinases that play a role in the growth and survival of cancer cells. By disrupting these pathways, the compound can potentially slow down or halt the progression of cancer, offering a new therapeutic approach for patients with various types of cancer.
Used in Myeloproliferative Disorders Treatment:
In addition to its cancer-fighting properties, 2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC ACID AMIDE is also used in the treatment of myeloproliferative disorders, which are a group of blood disorders characterized by the overproduction of certain blood cells. 2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC ACID AMIDE's inhibitory effects on Janus kinases can help regulate the abnormal cell production associated with these disorders, providing a potential therapeutic option for patients suffering from these conditions.

Check Digit Verification of cas no

The CAS Registry Mumber 4815-35-4 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 4,8,1 and 5 respectively; the second part has 2 digits, 3 and 5 respectively.
Calculate Digit Verification of CAS Registry Number 4815-35:
(6*4)+(5*8)+(4*1)+(3*5)+(2*3)+(1*5)=94
94 % 10 = 4
So 4815-35-4 is a valid CAS Registry Number.
InChI:InChI=1/C11H10N2OS/c12-10(14)8-6-9(15-11(8)13)7-4-2-1-3-5-7/h1-6H,13H2,(H2,12,14)

4815-35-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 20, 2017

Revision Date: Aug 20, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Amino-5-phenylthiophene-3-carboxamide

1.2 Other means of identification

Product number -
Other names 2-amino-5-phenylthiophene-3-carboxamide

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:4815-35-4 SDS

4815-35-4Relevant articles and documents

Thiophene carboxamide inhibitors of JAK2 as potential treatments for myleoproliferative neoplasms

Haidle, Andrew M.,Zabierek, Anna A.,Childers, Kaleen K.,Rosenstein, Craig,Mathur, Anjili,Altman, Michael D.,Chan, Grace,Xu, Lin,Bachman, Eric,Mo, Jan-Rung,Bouthillette, Melaney,Rush, Thomas,Tempest, Paul,Marshall, C. Gary,Young, Jonathan R.

, p. 1968 - 1973 (2014/04/17)

A series of carboxamide-substituted thiophenes demonstrating inhibition of JAK2 is described. Development of this chemical series began with the bioisosteric replacement of a urea substituent by a pyridyl ring. Issues of chemical and metabolic stability were solved using the results of both in vitro and in vivo studies, ultimately delivering compounds such as 24 and 25 that performed well in an acute PK/PD model measuring p-STAT5 inhibition.

Nf-kb inhibitors

-

, (2008/06/13)

The present invention provides novel compounds and methods for treating diseases with aminothiophene inhibitors of IKK-β phosphorylation of IκB.

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