4815-35-4

Usage

Uses

Used in Pharmaceutical Industry:
2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC ACID AMIDE is used as an inhibitor of Janus kinases for the treatment of myeloproliferative disorders and cancers. Its ability to inhibit these enzymes helps in controlling cell signaling pathways that contribute to the development and progression of these diseases.
Used in Cancer Treatment:
2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC ACID AMIDE is employed as an anticancer agent, targeting the inhibition of Janus kinases that play a role in the growth and survival of cancer cells. By disrupting these pathways, the compound can potentially slow down or halt the progression of cancer, offering a new therapeutic approach for patients with various types of cancer.
Used in Myeloproliferative Disorders Treatment:
In addition to its cancer-fighting properties, 2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC ACID AMIDE is also used in the treatment of myeloproliferative disorders, which are a group of blood disorders characterized by the overproduction of certain blood cells. 2-AMINO-5-PHENYL-THIOPHENE-3-CARBOXYLIC ACID AMIDE's inhibitory effects on Janus kinases can help regulate the abnormal cell production associated with these disorders, providing a potential therapeutic option for patients suffering from these conditions.

InChI:InChI=1/C11H10N2OS/c12-10(14)8-6-9(15-11(8)13)7-4-2-1-3-5-7/h1-6H,13H2,(H2,12,14)

Upstream product

• 1093877-97-4 benzyl [3-(aminocarbonyl)-5-iodo-2-thienyl]carbamate 
• 1093877-96-3 benzyl [3-(aminocarbonyl)-2-thienyl]carbamate 
• 14080-51-4 2-aminothiophene-3-carboxamide 
• 101-41-7 benzeneacetic acid methyl ester 
• 122-78-1 phenylacetaldehyde 
• 107-91-5 cyanoacetic acid amide 
• 60-12-8 2-phenylethanol 
• 103-82-2 phenylacetic acid 

Downstream Products

• 109164-39-8 N-(3-Carbamoyl-5-phenyl-thiophen-2-yl)-succinamic acid 
• 113260-44-9 2-acetamido-5-phenylthiophene-3-carboxamide 
• 113290-06-5 N,N'-diacetyl-2-amino-5-phenylthiophene-3-carboxamide 
• 113260-46-1 2-benzamido-5-phenylthiophene-3-carbonirtile 
• 113260-45-0 2-benzamido-5-phenylthiophene-3-carboxamide 
• 86126-60-5 6-phenylthieno<2,3-d>pyrimidine-2,4-dione 
• 515879-15-9 6-phenyl-3H-thieno[2,3-d][1,2,3]triazin-4-one 
• 109164-49-0 3-(4-Oxo-6-phenyl-3,4-dihydro-thieno[2,3-d]pyrimidin-2-yl)-propionic acid 
• 1093871-78-3 2-[(4-fluoropyridin-2-yl)amino]-5-phenylthiophene-3-carboxamide 
• 1093871-73-8 2-[(4-methylpyridin-2-yl)amino]-5-phenylthiophene-3-carboxamide 
• 1093871-76-1 2-[(5-fluoropyridin-2-yl)amino]-5-phenylthiophene-3-carboxamide 
• 1093871-88-5 2-[(5-(methylsulfonyl)pyridin-2-yl)amino]-5-phenylthiophene-3-carboxamide 
• 1093871-74-9 2-[(5-methylpyridin-2-yl)amino]-5-phenylthiophene-3-carboxamide 
• 1093871-87-4 5-phenyl-2-[(6-(trifluoromethyl)pyridin-2-yl)amino]thiophene-3-carboxamide 

Relevant academic research and scientific papers

Thiophene carboxamide inhibitors of JAK2 as potential treatments for myleoproliferative neoplasms

A series of carboxamide-substituted thiophenes demonstrating inhibition of JAK2 is described. Development of this chemical series began with the bioisosteric replacement of a urea substituent by a pyridyl ring. Issues of chemical and metabolic stability were solved using the results of both in vitro and in vivo studies, ultimately delivering compounds such as 24 and 25 that performed well in an acute PK/PD model measuring p-STAT5 inhibition.

Microwave-assisted synthesis of 5-substituted 2-aminothiophenes starting from arylacetaldehydes

An easy three-step pathway for the synthesis of arylacet-aldehydes from the corresponding carboxylic acids in very high yields is described. Their use as precursors of 5-substituted-2-aminothiophenes is illustrated via a microwave-assisted Gewald reaction. This method allows obtaining the expected compounds in a shorter time and with better yields and purities than the classical procedures. Georg Thieme Verlag Stuttgart - New York.

Nf-kb inhibitors

The present invention provides novel compounds and methods for treating diseases with aminothiophene inhibitors of IKK-β phosphorylation of IκB.

Novel Compounds

The invention relates to heteroaromatic carboxamides of formula (I), wherein A, R1, R2 and X are as defined in the specification, processes and intermediates used in their preparation, pharmaceutical compositions containing them and their use in therapy.