4816-94-8Relevant academic research and scientific papers
Iodoacetonitrile and bromoacetonitrile as alkylating reagents for the nitrogen-phosphorus detector
Shin, Ho-Sang,Kim, Seungki,Myung, Seung-Woon,Park, Jong-Sei
, p. 1853 - 1859 (2007/10/02)
Iodoacetonitrile and bromoacetonitrile were used to enhance the sensitivity of chromatographically difficult compounds. Selective derivatization occurs with acidic hydroxyl, amino, and amide functional groups but does not occur for the alcoholic hydroxyl
Antitumor and antiinflammatory agents: N-benzoyl-protected cyanomethyl esters of amino acids
Sajadi,Almahmood,Loeffler,Hall
, p. 1419 - 1422 (2007/10/08)
A series of N-protected cyanomethyl esters of various amino acids was synthesized and tested for antineoplastic and antiinflammatory activity in rodents. Utilizing the L-phenylalanine cyanomethyl ester and varying the N-protecting moiety demonstrated that the N-tosyl and the N-Cbz analogues were the most active against Ehrlich ascites cell proliferation. The N-(carbobenzyloxy)- and N-benzoyl-L-phenylalanine cyanomethyl esters were the most active against carrageenan-induced inflammation. In the N-benzoyl series of cyanomethyl esters, L-alanine, DL-valine, and L-leucine amino acid analogues were the most active against Ehrlich ascites cell proliferation. The glycine and L-alanine analogues possessed the best inhibitor activity and the ability to suppress the writhing reflex which is associated with inflammatory pain. However, no antipyretic or narcotic analgesic activity was demonstrated by these agents.
