51514-00-2

Upstream product

• 67-56-1 methanol 
• 1145-32-0 N-(N'-benzoyl-2-aminoethanoyl)-2-aminoethanoic acid 
• 4816-94-8 hippuric acid cyanomethyl ester 
• 616-34-2 methoxycarbonylmethylamine 
• 98-88-4 benzoyl chloride 
• 100-97-0 hexamethylenetetramine 
• 39687-95-1 isocyanoacetic acid methyl ester 
• 65-85-0 benzoic acid 
• 495-69-2 Hippuric Acid 
• 5680-79-5 glycine ethyl ester hydrochloride 

Downstream Products

• 1145-32-0 N-(N'-benzoyl-2-aminoethanoyl)-2-aminoethanoic acid 
• 51514-01-3 C₂₁H₃₈N₂O₄Si₃ 
• 122092-71-1 N-benzoylglycyl-α-methoxyglycine methyl ester 
• 91083-93-1 C₁₂H₁₂N₄O₇ 
• 91083-92-0 C₁₂H₁₂N₄O₈ 
• 95205-34-8 dinitrosated benzoylglycylglycine methyl ester 

Relevant academic research and scientific papers

The Ugly Duckling Metamorphosis: The Ammonia/Formaldehyde Couple Made Possible in Ugi Reactions.

Ugi reactions are still a challenge when the concomitant use of ammonia and formaldehyde is required. Herein, we propose a strategy to overcome this challenge using hexamethylenetetramine (HMTA) as a singular key for the employment of these two simple starting materials in the Ugi reaction. Acylaminoacetamide derivatives were prepared in good to excellent yields by this new methodology. The scope and optimization of the reaction conditions were investigated. This novel methodology was successfully applied in the synthesis of two different diketopiperazines (DKPs) using the Ugi/Deprotection+Activation/Cyclization (UDAC) method. A continuous flow approach was also used in this methodology.

A potential greener protocol for peptide coupling reactions using recyclable/reusable ionic liquid [ C 4-DABCO ] [ N(CN) 2 ]

Abstract : Development of greener methodologies in synthetic organic chemistry has brought awareness in recent decades due to the ecological performance of green solvent media and catalytic systems. Here, we carried out the peptide bond formation reaction in one of the environmentally secure solvents, ‘ionic liquids’ in the presence of coupling reagent and in the absence of external base at room temperature, affording dipeptides in good to excellent yields. GRAPHICAL ABSTRACT: SYNOPSIS We carried out the peptide bond formation reaction in ionic liquids in the presence of a coupling reagent at room temperature, in the absence of an external base, affording dipeptides in good to excellent yields.

A green protocol for peptide bond formation in WEB

A simple, efficient, and environmentally friendly approach has been developed for the synthesis of peptides in aqueous medium. In this work, peptides are easily synthesized in water extract of banana (WEB)/ethylene glycol and without using external base u