51514-00-2Relevant articles and documents
The Ugly Duckling Metamorphosis: The Ammonia/Formaldehyde Couple Made Possible in Ugi Reactions.
Rosalba, Thaissa Pasquali F.,Kas, Samia Sayegh A.,Sampaio, Ana Beatriz S.,Salvador, Carlos Eduardo M.,Andrade, Carlos Kleber Z.
, p. 2831 - 2842 (2021/05/13)
Ugi reactions are still a challenge when the concomitant use of ammonia and formaldehyde is required. Herein, we propose a strategy to overcome this challenge using hexamethylenetetramine (HMTA) as a singular key for the employment of these two simple starting materials in the Ugi reaction. Acylaminoacetamide derivatives were prepared in good to excellent yields by this new methodology. The scope and optimization of the reaction conditions were investigated. This novel methodology was successfully applied in the synthesis of two different diketopiperazines (DKPs) using the Ugi/Deprotection+Activation/Cyclization (UDAC) method. A continuous flow approach was also used in this methodology.
A green protocol for peptide bond formation in WEB
Konwar, Manashjyoti,Ali, Abdul Aziz,Sarma, Diganta
supporting information, p. 2283 - 2285 (2016/05/10)
A simple, efficient, and environmentally friendly approach has been developed for the synthesis of peptides in aqueous medium. In this work, peptides are easily synthesized in water extract of banana (WEB)/ethylene glycol and without using external base u
