4819-77-6

Usage

Uses

1,1,2-Triethoxyethane is used as a chemical intermediate for the synthesis of various pharmaceutical compounds, including COX-2 selective inhibitors and antiviral agents.
Used in Pharmaceutical Industry:
1,1,2-Triethoxyethane is used as an intermediate for the synthesis of pyrazolopyrimidine derivatives, which act as COX-2 selective inhibitors. These inhibitors are important in the development of anti-inflammatory and pain-relieving medications, as they help reduce inflammation and pain by selectively targeting the COX-2 enzyme.
1,1,2-Triethoxyethane is also used as an intermediate in the preparation of [(1,2,4-oxadiazolylphenoxy)alkyl]isoxazoles, which are antiviral agents. These compounds have potential applications in the development of treatments for various viral infections, including influenza and other respiratory illnesses.

Purification Methods

Dry it with Na2SO4, and distil it. [McElvain & Walters J Am Chem Soc 64 1964 1942, Beilstein 1 H 818, 1 I 418, 1 III 3184, 1 IV 3958.]

InChI:InChI=1/C8H18O3/c1-4-9-7-8(10-5-2)11-6-3/h8H,4-7H2,1-3H3

Upstream product

• 623-46-1 1,2-dichloro-2-ethoxyethane 
• 141-52-6 sodium ethanolate 
• 2983-26-8 1,2-dibromoethyl ethyl ether 
• 64-17-5 ethanol 
• 2032-35-1 Bromoacetaldehyde diethyl acetal 
• 621-62-5 chloroacetaldehyde diethyl acetal 
• 51806-20-3 1,1-diethoxy-2-iodoethane 
• 22056-82-2 ethoxyacetaldehyde 
• 123-63-7 paracetaldehyde 
• 462-95-3 formaldehyde diethyl acetal 
• 24332-20-5 methoxyacetaldehyde dimethylacetal 

Downstream Products

• 5344-23-0 diethoxyacetaldehyde 
• 74-96-4 ethyl bromide 
• 64-17-5 ethanol 
• 761-17-1 1,1-dibromo-2,2-diethoxy-ethane 
• 7732-18-5 water 
• 75-03-6 ethyl iodide 
• 17655-74-2 β-ethoxystyrene 
• 16484-86-9 1,2-diethoxyethylene 
• 68083-55-6 (2,4-dimethyl-phenyl)-acetaldehyde 
• 13975-23-0 1,2-bis(ethoxy)phenylethane 
• 860753-31-7 1,2-diethoxy-1-o-tolyl-ethane 
• 10166-08-2 2-methyl-benzeneacetaldehyde 
• 72927-80-1 (3-methylphenyl)acetaldehyde 
• 861529-20-6 1,2-diethoxy-1-(4-chloro-phenyl)-ethane 

Relevant academic research and scientific papers

ARYL-PYRIDINE DERIVATIVES AS ALDOSTERONE SYNTHASE INHIBITORS

The present invention provides a compound of formula (I) or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R4, R5 and n are defined herein. The invention also relates to a method for manufacturing compounds of the invention, and their therapeutic uses. The present invention further provides a combination of pharmacologically active agents and a pharmaceutical composition.

17O, 13C and 1H NMR spectra of 1,2-dialkoxyethenes

The 17O, 13C and 1H NMR spectra of a number of 1,2-dialkoxyethenes R1OCH=CHOR2 were recorded. The O atoms, in particular those of the E forms, are strongly shielded relative to the 17O nuclei of the corresponding alkyl vinyl ethers ROCH=CH2. Moreover, in compounds of the type ROCH=CHOMe, the difference δ(17O)Z - δ(17O)E of the MeO group decreases and that of the RO group increases with increasing bulkiness of R. These trends probably arise from changes, with the size of the alkyl group R, in the stereochemistry of the RO group of the E-isomer about the O - C(sp2) bond, whereas the stereochemistry of the Z-form seems to be independent of the size of R. Additional information on the stereochemistry of the title compounds is provided by their 13C and 1H NMR spectra.

Umsatz und kinetische Modellierung der Bildung von Formaldehyd, Ethylenglycol und Ameisensaeure bei der oxidativen Alkohol-Thermolyse

In this paper the investigation about oxy-thermolysis of simple organic compounds is extended to the formation of aldehyds, ethylene glycol, formic acid and others received from methanol and ethanol in the occurence of oxygen in the temperature range 900 K T 1100 K.Probable intermediate radicalic species are CH3O and CH2OH, kinetically treated as one kind of molecules.An improved system of reaction rate equations is solved.The calculated concentrations depending on time reach a maximum near 0.3 s and are compared with measured chemical concentrations.Finally it is given a sensitivity analysis of the reaction rate system.

CHEMISTRY OF ENOL ETHERS. LXXXVIII. CONDENSATION OF THE TETRAETHYLACETAL OF MALONALDEHYDE WITH β-SUBSTITUTED ENOL ALKYL ETHERS

The action of β-substituted enol ethers on the tetraethylacetal of malonaldehyde gave the acetals of 1,5- and 1,7-dialdehydes.The nature of the substituent in the enol ether was found to affect the regioselectivity of the reaction: condensation with ethers containig an electron-wthdrawing substituent leads to 1,5-dialdehyde acetals, while condensation with ethers containig a strong electron donor substituent leads to 1,7-dialdehyde acetals.