4825-70-1

Basic information

• Product Name: Benzene, 1,1'-[(1E,3S)-3-ethenyl-1-propene-1,3-diyl]bis[4-methoxy-
• CAS NO: 4825-70-1
• Molecular Formula: C19H20O2
• Molecular Weight: 280.367
• Mol File: 4825-70-1.mol
• Article Data: 4

Chemical Properties

• CAS DataBase Reference: Benzene, 1,1'-[(1E,3S)-3-ethenyl-1-propene-1,3-diyl]bis[4-methoxy-(CAS DataBase Reference)
• NIST Chemistry Reference: Benzene, 1,1'-[(1E,3S)-3-ethenyl-1-propene-1,3-diyl]bis[4-methoxy-(4825-70-1)
• EPA Substance Registry System: Benzene, 1,1'-[(1E,3S)-3-ethenyl-1-propene-1,3-diyl]bis[4-methoxy-(4825-70-1)

Safety Data

• Hazardous Substances Data: 4825-70-1(Hazardous Substances Data)

Upstream product

• 117295-79-1 1,3-bis-(4'-methoxyphenyl)pent-1-en-4-yne 
• 135966-00-6 1,3-Bis(4-methoxyphenyl)pent-4-en-1-ol 
• 41564-67-4 (E)-1,3-bis(4-methoxyphenyl)-2-propene-1-one 
• 135965-97-8 (-)-3-(4-methoxyphenyl)pent-4-enal 
• 24680-50-0 4-methoxy-trans-cinnamaldehyde 
• 104-92-7 1-bromo-4-methoxy-benzene 
• 100-06-1 1-(4-methoxyphenyl)ethanone 
• 123-11-5 4-methoxy-benzaldehyde 
• 2373-89-9 4,4'-dimethoxychalcone 
• 117295-77-9 1,3-bis(4'-methoxyphenyl)pent-4-yn-1-ol 
• 6388-72-3 2-(4-methoxyphenyl)oxirane 
• 22338-53-0 1,3-Bis(4-methoxyphenyl)pent-4-en-1-one 

Downstream Products

• 230292-85-0 (+/-)-Nyasol 

Relevant articles and documents

Practical Synthesis of (±)-Nyasol

A practical total synthesis of racemic nyasol (7) was explored. The α-hydroxyketo compound 3 was prepared from commercially available starting materials in two steps. Chelation-controlled reduction of the α-hydroxyketo compound 3 with Zn(BH4)s

Enantioselective total synthesis of the di-O-methyl ethers of (-)-agatharesinol, (+)-hinokiresinol and (-)-sugiresinol, characteristic norlignans of Coniferae

Facile enantioselective syntheses of the di-O-methyl ethers of the norlignans, (-)-agatharesinol (-)-1a, (+)-hinokiresinol (+)-2a and (-)-sugiresinol (-)-3a are described. Grignard addition of vinylmagnesium bromide to an aldimine (-)-13, prepared from the tert-butyl ester 11 and 4-methoxycinnamaldehyde 12, afforded a homochiral vinyl aldehyde, (-)-3-(4-methoxyphenyl)pent-4-enal (-)-14 in > 95% ee, which was converted into a diastereoisomeric mixture of 1,3-bis(4-methoxyphenyl)pent-4-en-1-ols (3R)-6 by a second Grignard reaction with 4-methoxyphenylmagnesium bromide. Sharpless' asymmetric dihydroxylation of the vinyl alcohols (3R)-6 proceeded diastereoselectively to give the triol of desired relative stereochemistry (2S,3S)-7. This, upon dehydration, afforded (-)-di-O-methylsugiresinol (-)-3b, the subsequent acid-catalysed cyclization of which gave (-)-di-O-methyl agatharesinol (-)-1b. (+)-Di-O-methylhinokiresinol (+)-2b was readily obtained by the dehydration of the vinyl alcohols (3R)-6.