483349-31-1

Upstream product

• 943-89-5 (E)-3-(4-methoxyphenyl)acrylic acid 
• 1017279-61-6 allyl-(1-chloromethyl-2,3-dihydro-1H-benzo[e]indol-5-yl)-amine 
• 4112-02-1 1-iodo-2,4-dinitronaphthalene 
• 161393-72-2 1,3-dinitronaphthalen-4-yl trifluoromethanesulfonate 
• 830-09-1 3-(4'-methoxyphenyl)propenoic acid 
• 483349-29-7 5-[allyl(tert-butyloxycarbonyl)amino]-3-(tert-butyloxycarbonyl)-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indole 
• 483349-25-3 (4-(tert-butoxycarbonylamino)-1-iodo-naphthalen-2-yl)carbamic acid tert-butyl ester 
• 24824-28-0 naphthalene-1,3-diamine 
• 605-69-6 1-hydroxy-2,4-dinitronaphthalene 
• 483349-27-5 5-(allyl(tert-butoxycarbonyl)amino)-1-((2,2,6,6-tetramethyl-piperidin-1-yloxy)methyl)-1,2-dihydrobenzo[e]indole-3-carboxylic acid tert-butyl ester 
• 483349-26-4 allyl-[3-(allyl-tert-butoxycarbonyl-amino)-4-iodo-naphthalen-1-yl]-carbamic acid tert-butyl ester 
• 483349-28-6 5-[allyl(tert-butyloxycarbonyl)amino]-3-(tert-butyloxacarbonyl)-1-(hydroxymethyl)-1,2-dihydro-3H-benzo[e]indole 

Downstream Products

• 204915-94-6 {1-chloromethyl-3-[3-(4-methoxy-phenyl)acryloyl]-2,3-dihydro-1H-benzo[e]indol-5-yl}-carbamic acid tert-butyl ester 
• 204915-50-4 (2E)-1-[5-amino-1-(chloromethyl)-1H,2H,3H-benzo[e]indol-3-yl]-3-(4-methoxyphenyl)prop-2-en-1-one 

Relevant academic research and scientific papers

A new short synthesis of 3-substituted 5-Amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indoles (Amino-CBIs)

A new short synthesis of 3-substituted 5-amino-1-(chloromethyl)-1,2-dihydro-3H-benzo[e]indoles from Martius Yellow is disclosed. The key steps of the synthesis were three efficient regioselective reactions (iodination, 5-exo-trig aryl radical-alkene cyclization and carboxylation).

PROCESSES FOR PREPARING 3-SUBSTITUTED 1-(CHLOROMETHYL)-1,2-DIHYDRO-3H-[RING FUSED INDOL-5-YL(AMINE-DERIVED)] COMPOUNDS AND ANALOGUES THEREOF, AND TO PRODUCTS OBTAINED THEREFROM

The invention provides processes of preparing 3-substituted 1-(chloromethyl)-1,2-dihydro-3H-[ring fused indol-5-yl(amine-derived)] compounds of formula (I) and its analogues, or a physiologically functional derivative thereof, (I), wherein A and B togethe