4838-35-1Relevant academic research and scientific papers
Novel green acylamide synthesis method through quaternary ammonium salt C-N bond fracture
-
Paragraph 0072-0074, (2017/04/19)
The invention provides a novel green acylamide synthesis method through quaternary ammonium salt C-N bond fracture. The structure of the compound is expressed by methods such as H NMR, C, NMR and HRMS and is confirmed. A series of phenmethyl quaternary ammonium salts and aminated compounds are used; under the catalysis effect of PdCl2(dppf), PPh3 is used as a ligand, Na2CO3 is used as the alkali, and corresponding amide compounds are generated in the 100-DEG C CO atmosphere in a pHMe/DMSO mixed solvent. The method has the advantages that the efficiency is high; the toxicity is low; the conditions are mild; the application range of the substrate is wide; the yield is high; the product purity is high; the separation is convenient; the method can be applicable to large-scale preparation; the application prospects are wide.
Non-Lactone Carbocyclic and Heterocyclic Antagonists and Agonists of Bacterial Quorum Sensing
-
Page/Page column 21-22, (2011/04/14)
Compounds which modulate quorum sensing in quorum sensing bacteria. Compounds of the invention inhibit quorum sensing and/or activate quorum sensing in various bacteria. Compounds that inhibit quorum sensing are particularly useful for inhibition of detri
Suzuki-Miyaura arylations of tetramic acid sulfonates: Evaluation of lactam protection, sulfonate esters, and sterics
Yoon-Miller, Sarah J. P.,Dorward, Kathryn M.,White, Kimberly P.,Pelkey, Erin T.
experimental part, p. 447 - 454 (2009/09/28)
(Chemical Equation Presented) The synthesis of 3,4-diaryl-3-pyrrolin-2-ones and 4-aryl-3-pyrrolin-2-ones using Suzuki-Miyaura cross-coupling reactions of tetramic acid sulfonates with arylboronic acids has been studied. The effect that sulfonate ester, st
Solution and solid-state models of peptide CH...O hydrogen bonds
Baures, Paul W.,Beatty, Alicia M.,Dhanasekaran, Muthu,Helfrich, Brian A.,Perez-Segarra, Waleska,Desper, John
, p. 11315 - 11323 (2007/10/03)
Fumaramide derivatives were analyzed in solution by 1H NMR spectroscopy and in the solid state by X-ray crystallography in order to characterize the formation of CH...O interactions under each condition and to thereby serve as models for these interactions in peptide and protein structure. Solutions of fumaramides at 10 mM in CDCl3 were titrated with DMSO-d6, resulting in chemical shifts that moved downfield for the CH groups thought to participate in CH...O=S(CD3)2 hydrogen bonds concurrent with NH...O=S(CD3)2 hydrogen bonding. In this model, nonparticipating CH groups under the same conditions showed no significant change in chemical shifts between 0.0 and 1.0 M DMSO-d6 and then moved upfield at higher DMSO-d6 concentrations. At concentrations above 1.0 M DMSO-d6, the directed CH...O=S(CD3)2 hydrogen bonds provide protection from random DMSO-d6 contact and prevent the chemical shifts for participating CH groups from moving upfield beyond the original value observed in CDCl3. X-ray crystal structures identified CH...O=C hydrogen bonds alongside intermolecular NH...O=C hydrogen bonding, a result that supports the solution 1H NMR spectroscopy results. The solution and solid-state data therefore both provide evidence for the presence of CH...O hydrogen bonds formed concurrent with NH...O hydrogen bonding in these structures. The CH...O=C hydrogen bonds in the X-ray crystal structures are similar to those described for antiparallel β-sheet structure observed in protein X-ray crystal structures.
3-ACYL-2-(N-CYANOIMINO)THIAZOLIDINES AS AN ACYLATING AGENT. PREPARATION OF AMIDES, ESTERS, AND THIOESTERS
Iwata, Chuzo,Watanabe, Mayumi,Okamoto, Shigeha,Fujimoto, Michitaro,Sakae, Masatoshi,et al.
, p. 323 - 326 (2007/10/02)
3-Acyl-2-(N-cyanoimino)thiazolidines proved to be powerful acylating agents.They reacted easily with amines, alcohols and thiols to give the corresponding amides, esters and thioesters in good yields.
