5467-51-6

Usage

Uses

Used in Pharmaceutical Industry:
(5Z)-5-(1H-indol-3-ylmethylidene)-1-phenylpyrimidine-2,4,6(1H,3H,5H)-trione is used as a potential therapeutic agent for targeting specific biological pathways. Its unique structure allows for the possibility of modulating various cellular processes, which could be beneficial in the development of new drugs to treat a range of diseases.
Used in Drug Design and Development:
In the field of drug design and development, (5Z)-5-(1H-indol-3-ylmethylidene)-1-phenylpyrimidine-2,4,6(1H,3H,5H)-trione serves as a valuable starting point for creating new molecules with improved pharmacological properties. Its structure can be further modified and optimized to enhance its interactions with biological targets, potentially leading to the discovery of more effective drugs.
Used in Research and Development:
(5Z)-5-(1H-indol-3-ylmethylidene)-1-phenylpyrimidine-2,4,6(1H,3H,5H)-trione is used as a research tool to study the interactions between small molecules and biological targets. Understanding these interactions can provide valuable insights into the molecular mechanisms underlying various diseases, which can, in turn, aid in the development of targeted therapies.
Further research is necessary to fully understand the properties and potential uses of (5Z)-5-(1H-indol-3-ylmethylidene)-1-phenylpyrimidine-2,4,6(1H,3H,5H)-trione, as its unique structure and potential interactions with biological targets make it a promising candidate for various applications in the field of medicinal chemistry.

Upstream product

• 855926-31-7 N-phenylthioacetyl-glycine amide 
• 1867-37-4 Benzylmalononitrile 
• 540-61-4 2-aminoacetonitrile 
• 100-52-7 benzaldehyde 
• 2700-22-3 Benzylidenemalononitrile 
• 53607-34-4 (2-bromo-2-nitroethyl)benzene 
• 103-80-0 phenylacetyl chloride 
• 151-63-3 cyanomethylamine sulfate 
• 151-63-3 aminoacetonitrile neutral sulfate 

Downstream Products

• 59-98-3 tolazoline 
• 1401249-42-0 C₁₄H₁₆N₂O₃S 
• 77055-33-5 N-phenacetyl glycine ethyl dithioester 
• 4838-35-1 N-(phenylacetyl)glycine ethyl ester 
• 500-98-1 phenylacetylglycine 

Relevant academic research and scientific papers

Sterically Demanding Oxidative Amidation of α-Substituted Malononitriles with Amines Using O2

An efficient amidation method between readily available 1,1-dicyanoalkanes and either chiral or nonchiral amines was realized simply with molecular oxygen and a carbonate base. This oxidative protocol can be applied to both sterically and electronically challenging substrates in a highly chemoselective, practical, and rapid manner. The use of cyclopropyl and thioether substrates support the radical formation of α-peroxy malononitrile species, which can cyclize to dioxiranes that can monooxygenate malononitrile α-carbanions to afford activated acyl cyanides capable of reacting with amine nucleophiles.

2-Substituted 4,5-dihydrothiazole-4-carboxylic acids are novel inhibitors of metallo-β-lactamases

Bacterial resistance to β-lactam antibiotics caused by class B metallo-β-lactamases (MBL), especially for certain hospital-acquired, Gram-negative pathogens, poses a significant threat to public health. We report several 2-substituted 4,5-dihydrothiazole-4-carboxylic acids to be novel MBL inhibitors. Structure activity relationship (SAR) and molecular modeling studies were performed and implications for further inhibitor design are discussed.

Umpolung reactivity in amide and peptide synthesis

The amide bond is one of natureg€s most common functional and structural elements, as the backbones of all natural peptides and proteins are composed of amide bonds. Amides are also present in many therapeutic small molecules. The construction of amide bonds using available methods relies principally on dehydrative approaches, although oxidative and radical-based methods are representative alternatives. In nearly every example, carbon and nitrogen bear electrophilic and nucleophilic character, respectively, during the carbong€"nitrogen bond-forming step. Here we show that activation of amines and nitroalkanes with an electrophilic iodine source can lead directly to amide products. Preliminary observations support a mechanism in which the polarities of the two reactants are reversed (German, umpolung) during carbong€"nitrogen bond formation relative to traditional approaches. The use of nitroalkanes as acyl anion equivalents provides a conceptually innovative approach to amide and peptide synthesis, and one that might ultimately provide for efficient peptide synthesis that is fully reliant on enantioselective methods.

Efficient transformation of aldoximes to nitriles using 2-chloro-1-methylpyridinium iodide under mild conditions

Various (aliphatic, aromatic, and heterocyclic aromatic) types of aldoximes were converted into the corresponding nitriles in good to excellent yields using 2-chloro-1-methylpyridinium iodide (CMPI) as a dehydrating agent under mild conditions.

Resonance Raman spectroscopic evidence for an intramolecular interaction involving th amide and dithioester groups of N-acyl glycine ethyl dithioesters

The synthesis and resonance Raman spectra of several new N-acyl glycine etyl dithioesters RC(=O)NHCH2C(=S)SR are reported.The resonance Raman spectra of these compounds contain at least two peaks in the "C=S stretching region" between 1050 and 1200 cmsup