4839-12-7Relevant academic research and scientific papers
Synthesis and pharmacology of 6-substituted benztropines: Discovery of novel dopamine uptake inhibitors possessing low binding affinity to the dopamine transporter
Simoni, Daniele,Rossi, Marcello,Bertolasi, Valerio,Roberti, Marinella,Pizzirani, Daniela,Rondanin, Riccardo,Baruchello, Riccardo,Invidiata, Francesco Paolo,Tolomeo, Manlio,Grimaudo, Stefania,Merighi, Stefania,Varani, Katia,Gessi, Stefania,Borea, Pier Andrea,Marino, Silvia,Cavallini, Sabrina,Bianchi, Clementina,Siniscalchi, Anna
, p. 3337 - 3343 (2007/10/03)
A series of 6α- and 6β-substituted benztropines were synthesized. A marked enantioselectivity was observed for the 6β-methoxylated benztropines, the (1R)-isomers being more potent than the corresponding (1S) compounds. The racemic 6α-methoxy-3-(4′,4″- dif
Effects of two-carbon bridge region methoxylation of benztropine: Discovery of novel chiral ligands for the dopamine transporter
Simoni, Daniele,Roberti, Marinella,Rondanin, Riccardo,Baruchello, Riccardo,Rossi, Marcello,Invidiata, Francesco Paolo,Merighi, Stefania,Varani, Katia,Gessi, Stefania,Borea, Pier Andrea,Marino, Silvia,Cavallini, Sabrina,Bianchi, Clementina,Siniscalchi, Anna
, p. 823 - 827 (2007/10/03)
6-Methoxylated and 8-oxygenated benztropines were prepared and evaluated for their DAT and SERT activity (binding and uptake inhibition). Methoxylation at the two-carbon bridge of benztropine produced a novel class of potent and selective DAT ligands. An
