483979-70-0Relevant academic research and scientific papers
Efficient synthesis of various atropisomeric amides in optically pure forms and their application to asymmetric reactions
Kitagawa, Osamu,Momose, Shu-ichi,Fushimi, Yoshihisa,Taguchi, Takeo
, p. 8827 - 8831 (1999)
Various atropisomeric amides were prepared in optically pure forms (≥98% ee) through the optical resolution of the amide ester derived from (R)-pantolactone, N-allyl-ortho-tert-butylaniline and oxalyl chloride. Asymmetric carbonyl addition reaction of an alkyllithium and asymmetric iodolactonization with these atropisomeric amides proceeded with high stereoselectivity.
