4840-12-4Relevant academic research and scientific papers
Diastereoselective Synthesis of Polycyclic Indolizines with 2-(2-Enynyl)pyridines and Enamines
Pathipati, Stalin R.,Van Der Werf, Angela,Selander, Nicklas
, p. 3691 - 3694 (2018)
A diastereoselective metal-catalyzed reaction of 2-(2-enynyl)pyridines and cyclic enamines is reported. The method provides access to a variety of substituted indolizine derivatives by variation of the enyne component and the reaction conditions. Performing the reaction using a preformed enamine led to the formation of polycyclic indolizines. With in situ generated enamines, ketone-containing indolizine derivatives were obtained. An asymmetric reaction of 2-(2-enynyl)pyridines and enamines generated from an aldehyde and a catalytic amount of amine is presented.
AN IMPROVED SYNTHESIS OF 4-CYCLOHEPTENE-1-CARBOXYLIC ACID
Marquardt, Donald J.,Newcomb, Martin
, p. 1193 - 1200 (2007/10/02)
Modification of the method of Stork and Landesman (J.Am.Chem.Soc. 1956, 78, 5129) permitted the synthesis of the title acid (1) in 58 percent yield from a cylopentanone enamine.Acid 1 is a useful intermediate for the preparation of 4-substituted cycloheptenes in good yields.
Analgesic N-{2-[N'-(2-furylmethyl and 2-thienyl-methyl)-N'-alkylamino]cycloaliphatic}cyanobenzamides
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, (2008/06/13)
Cis- and trans-N-(2-aminocycloaliphatic)benzamide compounds of the formula STR1 e.g., N-methyl-N-[2-(N-pyrrolidinyl)cyclohexyl]-3,4-dichlorobenzamide, and their pharmaceutically acceptable salts, have been found to have potent analgesic activity, and compositions containing these compounds useful in pharmaceutical dosage unit form for alleviating pain in warm blooded animals, as well as methods for alleviating pain in animals with these compositions. Processes for preparing the compounds are also disclosed.
Analgesic N-[2-(furyl-methylamino and 2-thienylmethylamino)cycloaliphatic]be
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, (2008/06/13)
Cis - and trans-N-(2-aminocycycloaliphatic)benzamide compounds of the formula STR1 e.g., N-methyl-N-[2-[(2-furylmethyl)methylamino]-cyclohexyl]-3,4-dichlorobenzamide, and their pharmaceutically acceptable salts, have been found to have potent analgesic activity, and compositions containing these compounds useful in pharmaceutical dosage unit form for alleviating pain in warm-blooded animals, as well as methods for alleviating pain in animals with these compositions. Processes for preparing the compounds are also disclosed.
Analgesic N-(2-aminocycloaliphatic)benzamides
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, (2008/06/13)
Cis- and trans-N-(2-aminocycloaliphatic)benzamide compounds of the formula STR1 E.G., N-methyl-N[2-(N-pyrrolidinyl)cyclohexyl[3,4-dichlorobenzamide, and their pharmaceutically acceptable salts, have been found to have potent analgesic activity, and compositions containing these compounds useful in pharmaceutical dosage unit form for alleviating pain in warm blooded animals, as well as methods for alleviating pain in animals with these compositions. Processes for preparing the compounds are also disclosed.
