4845-13-0Relevant academic research and scientific papers
Solid-phase synthesis of oxazolones and other heterocycles via Wang resin-bound diazocarbonyls
Yamashita, Makoto,Lee, Sang-Hyeup,Koch, Guido,Zimmermann, Juerg,Clapham, Bruce,Janda, Kim D.
, p. 5495 - 5498 (2007/10/03)
The preparation of Wang resin bound α-diazo-β-ketoesters is described. These highly useful intermediates were used for the synthesis of a series of heterocycle libraries, which were obtained from the resin using TFA cleavage. In addition, a novel route for the synthesis of oxazolones using an N-H insertion strategy is disclosed.
