4850-82-2

Usage

InChI:InChI=1/C18H16O4/c1-2-22-18(21)15(16(19)13-9-5-3-6-10-13)17(20)14-11-7-4-8-12-14/h3-12,15H,2H2,1H3

Upstream product

• 91-22-5 quinoline 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 98-88-4 benzoyl chloride 
• 613-90-1 benzoyl cyanide 
• 93-97-0 benzoic acid anhydride 
• 60-29-7 diethyl ether 
• 29392-77-6 sodium 3-ethoxy-3-oxo-1-phenylprop-1-en-1-olate 

Downstream Products

• 24477-14-3 ethyl 3,5-diphenylisoxazole-4-carboxylate 
• 62961-62-0 (Z)-3-hydroxy-1,3-diphenyl-2-propen-1-one 
• 2505-98-8 3,5-diphenyl-isoxazole-4-carboxylic acid 

Relevant academic research and scientific papers

2 -amino dibenzo [c, e] azepine compound and synthesis method thereof

The invention belongs to the technical field of organic chemistry, and particularly relates 2 - amine dibenzo [!c, eAzepine compound and a method for synthesizing the same. The method comprises the following steps: in an organic solvent in an inert gas atmosphere and a rare earth catalyst, continuous addition/cyclization reaction of 2 -nitrile -6 - alkynyl biphenyl with an amine to obtain 2 -aminobenzo [!c, eAzepine compound. A core structural unit - of the compound of the present invention is dibenzo [!c, eAzepine is widely found in the synthesis of biologically active molecules and natural products. The synthesis method is novel, has the advantages of mild reaction conditions, easily available raw materials, no need of any additives and additional ligands, no side reaction, high atom economy, simple operation, high product yield and the like.

Zinc-mediated alkylation and acylation of 1,3-dicarbonyl compounds

1,3-Dicarbonyl compounds undergo smooth allylation, benzylation, propargylation, and acylation with halides using metallic zinc in DMF at 60 °C to afford the corresponding allyl, benzyl, 2-propynyl, and acylated 1,3-diesters in good yields. In the case of cyclic 1,3-diketones, the corresponding enol ethers are obtained as sole products instead of C-alkylation.

SmCl3-catalyzed C-acylation of 1,3-dicarbonyl compounds and malononitrile

(Chemical Equation Presented) A recyclable, convenient, and efficient catalytic system for C-acylation of 1,3-dicarbonyl compounds and malononitrile with acid chlorides has been developed, giving moderate to excellent yields under mild conditions. This is the first catalytic example of such reactions. In addition, by applying this protocol as the key step, 3,5-disubstituted-1H- pyrazole-4-carboxylate can easily be synthesized in high yields in a one-pot procedure.