4850-82-2Relevant articles and documents
2 -amino dibenzo [c, e] azepine compound and synthesis method thereof
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Paragraph 12-13, (2021/09/15)
The invention belongs to the technical field of organic chemistry, and particularly relates 2 - amine dibenzo [!c, eAzepine compound and a method for synthesizing the same. The method comprises the following steps: in an organic solvent in an inert gas atmosphere and a rare earth catalyst, continuous addition/cyclization reaction of 2 -nitrile -6 - alkynyl biphenyl with an amine to obtain 2 -aminobenzo [!c, eAzepine compound. A core structural unit - of the compound of the present invention is dibenzo [!c, eAzepine is widely found in the synthesis of biologically active molecules and natural products. The synthesis method is novel, has the advantages of mild reaction conditions, easily available raw materials, no need of any additives and additional ligands, no side reaction, high atom economy, simple operation, high product yield and the like.
SmCl3-catalyzed C-acylation of 1,3-dicarbonyl compounds and malononitrile
Shen, Quansheng,Huang, Wen,Wang, Jialiang,Zhou, Xigeng
, p. 4491 - 4494 (2008/03/12)
(Chemical Equation Presented) A recyclable, convenient, and efficient catalytic system for C-acylation of 1,3-dicarbonyl compounds and malononitrile with acid chlorides has been developed, giving moderate to excellent yields under mild conditions. This is the first catalytic example of such reactions. In addition, by applying this protocol as the key step, 3,5-disubstituted-1H- pyrazole-4-carboxylate can easily be synthesized in high yields in a one-pot procedure.
